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ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...

The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...

PROJECT SUMMARYIn this projectwe propose to develop and demonstrate feasibility of a head mounted smartphone based application forin home training and remote monitoring of progress for patients with convergence insufficiencyCICI develops in anestimatedofschool agechildrenintheU Soverallandcausessymptomsofeyestrainblurredvisionand reduced concentrationresulting in significant educational disadvanta ...

Summary Since its discovery inLassa virusLASVa bi segmented RNA virus from the family Arenaviridaehas been recognized as the cause of disease affecting a quarter million people per yearresulting indeaths annually in West AfricaDue to global travelthere have been numerous confirmed cases of LASV infection outside West Africa including the USIts ability to spread as an aerosol and a case fatality ra ...

Project Summary AbstractThe goal of the proposed SBIR program is to develop a pharmaceutical manufacturing decontamination system using the innovative PSI atmospheric pressure microwave microplasma technologyCommercialization of this technology is targeted to replace the use of vapor phase hydrogen peroxideVPHPin parenteral drug manufacturing facilitiesincluding barrier isolator sterilization syst ...

The goal of this Phase I STTR project is to constructoptimizeand test a clinically viable intravascular near infrared fluorescence intravascular ultrasoundNIRF IVUSimaging catheter for simultaneous molecular and structural diagnosis of coronary artery diseaseCADCAD is a worldwide leading cause of death and disabilityincluding acute myocardial infarctioncongestive heart failureand sudden cardiac de ...

Project Summary The goal of this project is to introduce a new microcatheter that will significantly improve an interventional radiologist s ability to navigate across small blood vesselsMicrocatheters are designed to reach small vascular targets from access points such as the femoral or radial arterieslocated up tocm awayInterventional radiologists use these devices to treat a wide variety of ail ...

Project Summary Opioid drugssuch as morphine and oxycodoneare generally the most effective compounds available for treatment of moderate to severe painwhich affects nearlymillion adults in the United StatesIn spite of their analgesic efficacythe use of opioids is limited by an often lethal cluster of side effectsRapid tolerance leads to quickly escalated dosingwhile intolerable withdrawal symptoms ...