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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Small Molecule Treatments to Enhance Neurological Recovery After Stroke

    SBC: Stemetix, Inc.            Topic: NINDS

    PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD

    SBC: AcuraStem Inc.            Topic: 101

    Optimization and validation of PIKFYVE antagonism as a therapy for C ORFALS FTD Project SummaryAbstract The C ORFrepeat expansion mutation is the most common cause of amyotrophic lateral sclerosisALSand frontotemporal dementiaFTDaccounting for overof ALS cases in northern Europe andof cases worldwidemaking it a critical target for therapeutic interventionUsing patient specific stem cell based dise ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. HEART: Adding Memory to Reasoning: macHine lEArning tailoRed drug Titration

    SBC: Optima Integrated Health Inc.            Topic: NHLBI

    HypertensionHTNaffectsmillion Americanswith an annual hospitalization cost of $billion yearClinical trial outcomes of optima BPO BPa clinical reasoning artificial intelligenceAIsystemdetermined that the success failure of past anti HTN medication treatments can be utilized to improve O BP predictive performanceOur objective for this Phase I proposal is to investigate the feasibility of building a ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Neural Modulation System for In-Home Treatment of Overactive Bladder

    SBC: Theranova LLC            Topic: NIA

    Abstract Overactive bladder is a chronic and devastating condition in the aging populationApproximatelymillion people in the United States suffer from overactive bladderOABand associated urge incontinenceUIa chronic medical condition that drastically impairs quality of life and results in an annual economic burden of $billionThe psychological aspects of this chronic voiding dysfunction are particu ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Preclinical development of Novo29, a new antibiotic

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: R

    Abstract The overall goal of this project is to conduct preclinical studies on Novoour newly discovered bactericidal compoundAs drug resistance continues to spreadnew classes of antibiotics are needed to combat infections by pathogens such as methicillin resistant Staphylococcus aureusMRSAand vancomycin resistant EnterococciVRENovois a novel class of peptidoglycan synthesis inhibitor with favorabl ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. A Phase 2a Multicenter, Randomized, Vehicle-Controlled, Dose Escalating Study to Evaluate the Safety, Efficacy and Pharmacokinetics of CBT-001 Ophthalmic Solution in Pterygium Patients

    SBC: CLOUDBREAK THERAPEUTICS LLC            Topic: N

    Pterygium is an ocular surface disease with abnormal fibrovascular growth on the cornea that affects aboutmillion individuals in the USLater stage disease impairs vision and the current standard of care is surgical removal of lesion tissueHoweverlesions recur in aboutof patients after surgeryBecause there is no approved drug to treat pterygiumwe propose to address this unmet medical need with a to ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. FAST platform for same-shift, complete antibiotic menu antibiotic susceptibility testing

    SBC: SeLux Diagnostics            Topic: R

    The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Humanized Anti-Renalase Antibodies for Unresectable Melanoma

    SBC: BESSOR PHARMA, LLC            Topic: 102

    Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Culture-free identification of pathogens common in endocarditis directly from patient specimens

    SBC: HELIXBIND INC.            Topic: NIAID

    PROJECT SUMMARY Infective EndocarditisIEis a life threatening disease that affects roughlyAmericans annuallyIE is characterized by microbial vegetations on the endocardial surface which induce serious heart damage and persistent bloodstream infectionsBSIsleading to sepsisLeft untreated IE is fatalAmong the criteria to establish IE and treat patients most effectivelyblood cultures are indispensable ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. CFI Pathogen Inactivation of Human Plasma Units

    SBC: APHIOS CORPORATION            Topic: NHLBI

    PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...

    SBIR Phase I 2018 Department of Health and Human Services
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