Award Data

PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

Optimization and validation of PIKFYVE antagonism as a therapy for C ORFALS FTD Project SummaryAbstract The C ORFrepeat expansion mutation is the most common cause of amyotrophic lateral sclerosisALSand frontotemporal dementiaFTDaccounting for overof ALS cases in northern Europe andof cases worldwidemaking it a critical target for therapeutic interventionUsing patient specific stem cell based dise ...

HypertensionHTNaffectsmillion Americanswith an annual hospitalization cost of $billion yearClinical trial outcomes of optima BPO BPa clinical reasoning artificial intelligenceAIsystemdetermined that the success failure of past anti HTN medication treatments can be utilized to improve O BP predictive performanceOur objective for this Phase I proposal is to investigate the feasibility of building a ...

Abstract Overactive bladder is a chronic and devastating condition in the aging populationApproximatelymillion people in the United States suffer from overactive bladderOABand associated urge incontinenceUIa chronic medical condition that drastically impairs quality of life and results in an annual economic burden of $billionThe psychological aspects of this chronic voiding dysfunction are particu ...

Abstract The overall goal of this project is to conduct preclinical studies on Novoour newly discovered bactericidal compoundAs drug resistance continues to spreadnew classes of antibiotics are needed to combat infections by pathogens such as methicillin resistant Staphylococcus aureusMRSAand vancomycin resistant EnterococciVRENovois a novel class of peptidoglycan synthesis inhibitor with favorabl ...

Pterygium is an ocular surface disease with abnormal fibrovascular growth on the cornea that affects aboutmillion individuals in the USLater stage disease impairs vision and the current standard of care is surgical removal of lesion tissueHoweverlesions recur in aboutof patients after surgeryBecause there is no approved drug to treat pterygiumwe propose to address this unmet medical need with a to ...

The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

PROJECT SUMMARY Infective EndocarditisIEis a life threatening disease that affects roughlyAmericans annuallyIE is characterized by microbial vegetations on the endocardial surface which induce serious heart damage and persistent bloodstream infectionsBSIsleading to sepsisLeft untreated IE is fatalAmong the criteria to establish IE and treat patients most effectivelyblood cultures are indispensable ...

PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...