List

During this Phase I SBIR project, Electronic BioSicences (EBS) will develop a direct, long-read, RNA strand sequencing methodology that is capable of sequencing both canonical and specific modified nucleotides with high-accuracy. This will result in the development of technology wherein a single-stranded RNA (ssRNA) molecule is translocated through a nanopore reader using an applied voltage bias a ...

There is an increasing appreciation that dogs with naturally occurring cancers may be a better model system for evaluating cancer therapeutics than the traditional mouse model systems. However, use of dogs for evaluating the emerging class of immunotherapeutics for oncology is limited by the availability of suitable reagents to mentor the response of the canine immune system. The majority of reage ...

In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

c Mycand KRas dependent cancerssuch as colorectal cancerrepresent major unmet medical needs that currently lack targeted therapyRecent scientific advances revealed that theseundruggableoncogenes critically depend on post translational modification with the small ubiquitin like modifierSUMOfamily of proteinsand inhibiting SUMOylation inhibits c Myc and KRasFurthermoreSUMOylation inhibition can acti ...

Abstract E cigaretteE ciguse has rapidly proliferated worldwideIt is speculated that E cig use may exceed conventional cigarette use withinyearsCigarette smoking is the leading preventable cause of death and disabilityAs E cigs are a relatively new productstudies are needed to determine their long term detrimental effectssome of which may be similar to the long term detrimental effects of nicotine ...

DESCRIPTIONprovided by applicantThe goal of this Fast Track SBIR is to demonstrate the functionality of PROFUSAandapos s novel injectable tissue oxygen monitors in patients with peripheral arterial diseasePADand to determine the its ability to detect restenosis in critical limb ischemiaCLIPAD is a manifestation of systemic atherosclerosis that affectsmillion people in the U Swith prevalence increa ...

PROJECT SUMMARY Elderly patients are the largest consumers of prescription and non prescription medications and have been reported to account for $million in treatment costs for medication errors likely due to altered pharmacokineticspolypharmacydecline in cognitionand lower health literacyAs a result of this confluence of issues that affect the aging populationmedication management tools designed ...

Project Summary Tobacco attributable disease remains the largest potentially modi able cause of mortalityStrategies to reduce smoking prevalence include developing more effective smoking cessation treatmentsNicotine metabolism and dependence are predictors of smoking behaviorsincluding response to smoking cessation treatmentsThe goal of this Phase II project is to develop prediction models of nico ...

PROJECT SUMMARY In response to the growing need for training on interventions to address first episode psychosisthe Center for Social InnovationChas partnered with experts in Coordinated Specialty CareCSCto develop and test CSC OnDemandAn Innovative Online Learning Platform for Implementing Coordinated Specialty CareThe product builds on the findings of the Recovery After an Initial Schizophrenia ...

PROJECT SUMMARYABSTRACT Stroke affects overmillion patients in the U Swith an estimatedadditional cases of stroke occurring each yearOverof stroke survivors have spasticitya disorder of muscle tone that can cause striking impairments in functional movementPharmacologicalsurgical and physical treatments to manage spasticity haveat bestshort term efficacy and are confounded by side effectsIn this NI ...