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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Topic 377: Bridging the Guideline Implementation Gap: Clinical Decision Support to Improve Cancer Symptom Management

    SBC: Cognitive Medical Systems, Inc.            Topic: NCI

    Advances in clinical research have yielded many evidence-based guidelines to help clinicians provide the right care for the right patient at the right time; however, studies suggest that nearly half the time, that care does not reach the patient. Clinical decision support (CDS) is an information technology-enabled method to identify missed opportunities and optimize care. This proposal seeks to sy ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 371: Validation and Optimization of RP-185 as Adjuvant to Exploit the Immune Response Generated by Radiation

    SBC: Riptide Bioscience, Inc.            Topic: NCI

    Radiotherapy, a key anticancer therapy, acts not only by killing cancer cells, but also by activating the body's immune system to attack the remaining cancer cells. However, the immune-stimulating effect is weakened by the tumor's capacity to reprogram immune cells, particularly macrophages, so that they instead actively promote tumor growth. RP-185 (Riptide Biosciences, Vallejo, CA),an engineered ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 376: A noninvasive PET imaging strategy for longitudinal monitoring of immune contexture in the tumor microenvironmen

    SBC: CELLSIGHT TECHNOLOGIES, INC.            Topic: NCI

    Immunotherapy has transformed cancer treatment, but therapy response ranges between 5% to 60% depending on tumor and treatment type. Accumulating evidence points to number and type of immune cell infiltrates within tumors as the culprit for failure. To enable higher success rates, novel treatments aim to prime tumors for immunotherapy by improving the immune milieu within the tumor microenvironmen ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 378: PRORAD- A Mobile Application for Patient Related Outcomes of Radiotherapy

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: NCI

    Cancer patients receiving radiation therapy experience toxic side effects of the radiation, and sensitivity to radiation is variable across both patients and tumors, and is poorly understood. This Phase I SBIR project aims to design and demonstrate the feasibility of a Patient Reported Outcome mobile application for surveillance of RADiotherapy toxicity (PRORAD) that integrates NIH's Patient Repor ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 374: Sustained Delivery of PARP Inhibitors for Cancer Chemoprevention

    SBC: TheraNano LLC            Topic: NCI

    Here we propose to study two injectable formulations that provide different delivery routes for Talazoparib, potent PAPR inhibitor: An implant, InCeT-Talazoparib, which can be injected directly in the tumor where it will act as a sustained release depot of Talazoparib over a prolonged period of approximately 30 days. It delivers 100% of the drug to the tumor site with almost no systemic toxicity. ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 343- Cognitive Assessment and Monitoring Platform For Integrative Research (CAMPFIRE II)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: NCI

    Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 363- CONNECTING CANCER CAREGIVERS TO CARE TEAMS: DIGITAL PLATFORMS TO SUPPORT INFORMAL CANCER CAREGIVING

    SBC: Medable Inc.            Topic: NCI

    TOGETHER is a mobile application on a smart software system that informal caregivers will use to develop and implement home-based care for cancer survivors. It will help alleviate the cancer caregiving burden and facilitate communication with patients' healthcare teams by centering the conversation around a care plan. The goal of this Fast-Track project is to develop and validate a final TOGETHER ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Topic 345: RadTox- Measuring Radiation Toxicity using Circulating DNA

    SBC: DiaCarta, Inc.            Topic: NCI

    The QuantiDNA RadTox System is a unique, patented technology that measures tissue damage shortly following injury using cell-free DNA from a drop of blood. Premised on murine and primate studies showing circulating DNA is logarithmically increased with whole-body radiation dose, RadTox has the potential to overcome many of the species-specific challenges faced by biomarker panels. The phase I SBIR ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Topic 349: Quantum Dot FRET Immunoassay to Quantify Intramolecular Epitopes of Analytes in Tissue Sections

    SBC: Ocean Nanotech LLC            Topic: NCI

    This proposal is to develop a novel slide based proximity assay platform to quantify protein phosphorylation on tissues. The novelty of this assay platform is derived from the use of the quantum dot with two emission peaks for fluorescence resonance energy transfer (FRET): one emission as internal standard and the other as FRET donor. Change of ratio of the two emission intensity during the FRET c ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Topic 373: alteRNAting-seq

    SBC: ELECTRONIC BIOSCIENCES, INC.            Topic: NCI

    During this Phase I SBIR project, Electronic BioSicences (EBS) will develop a direct, long-read, RNA strand sequencing methodology that is capable of sequencing both canonical and specific modified nucleotides with high-accuracy. This will result in the development of technology wherein a single-stranded RNA (ssRNA) molecule is translocated through a nanopore reader using an applied voltage bias a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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