Award Data

Not Available Recent discoveries of plant-like organelles in Plasmodium falciparum, the organism that causes malaria, provide potential new avenues toward treatment and prevention of this deadly disease. More specifically, it is now known that the Shikimate Pathway, an enzymatic pathway that provides essential aromatics, is vital to the survival of P. falciparum. By blocking any of the seven enzy ...

DESCRIPTION (provided by applicant): In this SBIR project, PartTec will develop a detector that can support the high precision requirements of Intensity Modulated Proton Therapy, the next-generation Proton Therapy. There are no detectors currently available that meet the design goals of this project, in particular high spatial and timing resolution. While efforts have been started in this area ...

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Not Available Painted coatings are not perfect and their integrity is constantly challenged. During everyday use, scratches or scribes are often introduced into a coating. Where this occurs, the underlying metal is exposed directly to the environment and this favors accelerated corrosion. Thus, there is a need for so-called smart coatings that can spontaneously heal themselves wherever they are d ...

DESCRIPTION (provided by applicant): Over one million prostate biopsies are performed in the US each year to diagnose approximately 200,000 cases of prostate cancer. The majority of these biopsies are performed needlessly. The overall objective of this project is to develop a secondary prostate cancer diagnostic test that can be performed on men with elevated PSA in order to identify patients in n ...

DESCRIPTION (provided by applicant): Our long-term goal is to develop a novel therapeutic strategy for childhood acute lymphoblastic leukemia (ALL), with focus on relapsed T-cell leukemia. We intend to accomplish this by targeting a unique molecular masterregulator using a new generation of compounds. ALL is the most frequent cancer of the childhood. Although significant progress has been achieved ...

DESCRIPTION: Development of an Intelligent Sample Introduction System for Mass Spectrometry There is a pressing need for new technologies that enable rapid measurements without significant compromise to the analytical data. Herein, we propose to develop arobust mass spectrometry (MS) based surface sampling device that enables direct analysis of a variety of materials including biological tissue a ...

DESCRIPTION (provided by applicant): Over 8 million Americans have peripheral vascular disease (PAD). Percutaneous transluminal artery (PTA) treatment of severe PAD involves the use of balloons and stents, but delivery of these therapies is often suboptimal due to inaccuracies in angiographic assessment of vessel size or a lack of proper functional vessel assessment. Additional tools aid clinician ...

DESCRIPTION (provided by applicant): Transseptal (TS) access for left heart procedures is an important and rapidly growing space for diagnostics and therapy delivery with an expected total of over 10 million U.S. patients. In the U.S. and/or Europe, TS access procedures are used for atrial fibrillation (AF) ablation, left atrial appendage (LAA) closure, patent foramen ovale (PFO) closure, and trea ...

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is a national and worldwide epidemic that places the largest clinical and economic burden on the healthcare system of any disease condition. Patients with stable and acute coronary conditions are often treated with percutaneous coronary intervention (PCI), including stenting. Up to 85% of all coronary stents are under-deployed lead ...