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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Remote focusing through spatial light modulation for multifocal multiphoton micro

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with fast acquisition schemes to allow imaging of live, moving specimens at high NA. This combination allows for high-resoluti ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Novel VLP Adjuvant based on the VesiVax system

    SBC: Euclid Diagnostics LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Over one million prostate biopsies are performed in the US each year to diagnose approximately 200,000 cases of prostate cancer. The majority of these biopsies are performed needlessly. The overall objective of this project is to develop a secondary prostate cancer diagnostic test that can be performed on men with elevated PSA in order to identify patients in n ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Vitamin B6 based prodrugs of gemcitabine

    SBC: MBC Pharma, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): The long-term goal of this proposal is to develop more effective therapies for cancer, specifically pancreatic cancer. The specific focus of this proposal is to improve upon the anti-cancer activity of the drug gemcytabine. This will be accomplished by synthesizing novel conjugates of gemcytabine in a form that enables increased pathways for uptake into cancer ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. NIEHS- Device Agnostic Environmental/Agent Data Collection and Integration with

    SBC: APEX Therapeuitcs, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Our long-term goal is to develop a novel therapeutic strategy for childhood acute lymphoblastic leukemia (ALL), with focus on relapsed T-cell leukemia. We intend to accomplish this by targeting a unique molecular masterregulator using a new generation of compounds. ALL is the most frequent cancer of the childhood. Although significant progress has been achieved ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Small Molecule Inhibitors of the BCL6 Oncoprotein

    SBC: LOHOCLA RESEARCH CORPORATION            Topic: NIDA

    DESCRIPTION (provided by applicant): Chronic pain syndromes affect 25-35% of populations around the world. The presence of chronic pain generates a massive toll on quality of life, workforce productivity and healthcare resource utilization. Although non-opiate medications have been introduced to treat chronic pain syndromes, many types of chronic/neuropathic pain do not respond to such medications ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Production of human MUC17 (CRD1-L-CRD2) recombinant protein in rice for the treat

    SBC: VENTRIA BIOSCIENCE            Topic: NIDDK

    DESCRIPTION (provided by applicant): Recent studies in animal models demonstrate that an endogenous human intestinal mucin fragment, termed MUC17, augments intestinal cell restitution and enhances healing of experimental colitis, potentially opening a newdoor to effective treatment of ulcerative colitis. However, expression of MUC17 in E. coli, yeast, and insect cells has met great challenges due ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Low-cost proinsulin-transferrin fusion protein in rice for treatment of diabetes

    SBC: VENTRIA BIOSCIENCE            Topic: NIDDK

    DESCRIPTION (provided by applicant): Diabetes has become a devastating epidemic worldwide. Insulin is commonly used as a treatment to help manage diabetes because of its ability to control blood glucose levels, and is in high demand worldwide, but it facesmultiple challenges including adverse metabolic side-effects, short in vivo pharmaceutical life, and high cost. Today, millions of people contin ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. Quantum Dot Sensors for Superfund Priority Substances

    SBC: TDA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): The principal aim of this project is to obtain proof-of-concept for a new nanotechnology-based sensor material for rapid and sensitive fluorescence detection of polycyclic aromatic hydrocarbons (PAHs) and polychloro biphenyls (PCBs). Simple, cheap and safe methods to detect and quantify these toxic substances, which rank high in the ATSDR Substance Priority Lis ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Realistic Accurate Dosimulation (RAD)

    SBC: ENVIROFIT INTERNATIONAL, LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): The ambient concentration of airborne pollutants such as CO and PM2.5 particulates in rural homes of developing countries such as Kenya has been observed to exceed World Health Organization (WHO) exposure limits up to 30X, and US Environmental Protection Agency limits by 100X. This indoor air pollution (IAP) has been linked to nearly 3% of the global burden of ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO

    SBC: Sharklet Technologies Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): The exponential increase of diabetics and the elderly in the U.S. has at least tripled cataract surgeries in just two decades. As many as half of these surgeries will lead to posterior capsular opacification (PCO), which requires follow-up surgery using Nd:YAG laser capsulotomy. Without this additional surgery, patients can suffer permanent vision loss. In many ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
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