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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse

    SBC: Very Real Help, LLC            Topic: 104

    PROJECT SUMMARY/ABSTRACT Depression and anxiety rank among the largest public health burdens worldwide. While effective first-line treatments like cognitive behavioral therapy have been shown to be effective, there are numerous barriers to accessing this kind of clinician delivered care (e.g., cost, provider availability, stigma). There is a critical need for effective and affordable interventions ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A Robotic System to Remove Bladder Tumors Intact: The Key to Making Lifesaving Treatment Decisions

    SBC: VIRTUOSO SURGICAL, INC.            Topic: NIBIB

    Project Summary/Abstract: The objective of this proposal is to create a new robotic system that enables bladder tumors to be removed completely and intact. Currently they are removed piecemeal, which spreads cancer cells, and results in incon- clusive diagnosis and staging, which dramatically increases morbidity and mortality for patients. Our system will deliver two needle-sized, tentacle-like ar ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Neural organoid models of the immunological microenvironment of glioblastoma for drug discovery applications

    SBC: STEM PHARM, INCORPORATED            Topic: 102

    Project Summary/Abstract Glioblastoma (GBM) is the most prevalent primary brain tumor in adults with extremely poor survival rates and largely unchanged standard of care. While there are many challenges to developing better GBM treatments, one of the major challenges is the immune-suppressive environment commonly found within GBM tumors. This immune-suppressive nature results in a tumor that is no ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Auto-Titrating Oral Appliance for Sleep Disordered Breathing

    SBC: RUSH RIVER RESEARCH CORP            Topic: NHLBI

    Project Summary/Abstract Rush River Research Corp. (RRR) proposes to develop an auto-titrating oral appliance that fits fully-in-the-mouth for Sleep Disordered Breathing (SDB) therapy. SDB, resulting from airway obstruction, is directly linked to the four most costly diseases in the United States: heart disease, diabetes, obesity, and cancer. Research has shown that SBD sufferers are three times m ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Validation and Improvement of ISPRI-HCP: An Innovative Platform for Immunogenicity Risk Assessment of Process-related Protein Impurities

    SBC: EPIVAX, INC.            Topic: NIAID

    ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Precision Guidance of Resuscitation and Deresuscitation in Sepsis

    SBC: DAXOR CORPORATION            Topic: 300

    ABSTRACT Sepsis impacts 1.7 million Americans annually, leading to 270,000 deaths and $62 billion in costs. Most of the sepsis treatment follows the Surviving Sepsis Campaign (SSC) guidelines, consisting of early antibiotics, liberal fluid resuscitation, and vasopressor use in persistent hypotension. However, the fundamental assumption that sepsis universally results in high capillary leak leading ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. IND-enabling studies of an intranasal, single-replication M2SR influenza vaccine

    SBC: FLUGEN INC            Topic: NIAID

    ABSTRACT Influenza (flu) virus, an NIAID category C priority pathogen, causes a respiratory disease resulting in over 200,000 hospitalizations and ~ 36,000 deaths per year in the US, while global influenza pandemics have resulted in as many as 50-100 million deaths worldwide. To address this threat to public health, annual vaccination is recommended for all individuals aged over 6 months in the US ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid structure-based software to enhance antibody affinity and developability for high-throughput screening: Aiming toward total in silico design of antibodies

    SBC: DNASTAR, INC.            Topic: NIAID

    Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicit cellular responses that treat or cure disease. Discovering therapeutic antibodies traditionally requires costly and labor- intensive, laboratory-based screening experiments. Computational approaches that select antibodies with the most desirable pharmaceutical properties are thus poised to improve ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid, Handheld, Point-of-Care Stool Sample-prep Device for the Extraction and Detection of Nucleic Acid from Diarrheal Pathogens

    SBC: Godx Inc.            Topic: NIAID

    Abstract Diarrheal disease is a major health issue worldwide resulting in nearly 500,000 deaths annually in children under 5 years of age. Those who survive have higher risk of stunted growth and cognitive development. Identification of the gastrointestinal (GI) pathogens that cause diarrheal disease helps guide effective treatment. Currently, in the developed world, this is done using multiplexed ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Point-of-care lateral flow immunoassay for diagnosis of pertussis

    SBC: DXDISCOVERY INC            Topic: NIAID

    Pertussis (Whooping cough) is a highly contagious, airborne disease that is rapidly re-emerging as a serious public health threat in the United States. Despite high vaccine coverage, annual reported cases in the U.S. have been increasing recently, with an average of 25,000 per year from 2010-2019. This is a level unseen since the early 1960s. Diagnosis of pertussis is challenging because its early ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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