Award Data

Abstract: Immunophotonics is a biotech company developing a synthetic biopolymer, IP-001, to potentiate a systemic immunotherapy via microwave (MWA) thermal tumor ablation for treatment of Hepatocellular carcinoma (HCC). The goal of this SBIR Fast Track is to complete preclinical safety and efficacy testing to support an investigational new drug (IND) application based on the feedback from a meeti ...

Our innovation, Focused LIBS for Elements in Water IDentification (FLEW.ID), is a compact, cost-effective, and sensitive instrument for monitoring the elemental composition of aqueous solutions in plant growth systems on-board the International Space Station (ISS). FLEW.ID utilizes a miniaturized, low-pulse energy laser for performing laser-induced breakdown spectroscopy (LIBS) measurements that, ...

High temperature heat acquisition and transport is a critical technology gap inhibiting full implementation of nuclear energy propulsion (NEP) and power sources for NASA inter-planetary and Lunar Surface missions.nbsp; Nuclear energy thermal management requires acquisition and transport of 4-10MW of power at 1200-1400K; the target axial heat flux is 1.0MW/m2.nbsp; Furthermore, NASA requires candid ...

It is important to consider lithium-ion battery limitations particularly regarding temperature range, to ensure safe and successful mission outcomes. We have developed a gel polymer electrolyte that meets stringent requirements of high safety, stability, and non-flammabilitynbsp;for implantable medical devices and plannbsp;to further developnbsp;this electrolyte for use in cells operating in extre ...

The proposed product is designed to meet a high unmet medical need for osteosarcoma (OS), a rare pediatric cancer. OS accounts for 2% of childhood cancers (60% of cases occurring in patients who are 10-20 years of age).(1) OS 5-year survival is 70% for non-metastasized disease, 30% for metastasized primarily as a result of its highly metastatic and drug-resistant nature. Cytotoxic chemotherapy and ...

NASA has previously developed its 3D-TPS conceptnbsp;which offers superior mass efficiency relative to legacy carbon-phenolic TPS.nbsp; Multiple 3D-TPS recipes developed to date includenbsp;a spun carbon:phenolic yarn constituent.nbsp; Future recipes may require alternate yarn constructionsnbsp;(denier, blend ratios, fiber chemistries, etc.) in order to tailor TPS properties to specific mission re ...

To effectively monitor plant nutrient uptake and cycling, optimize fertilizing and watering routines, and reproducibly grow healthy plants for consumption, researchers on board the space station must know the concentration of key elements, nutrients, and other constituents present in plant growth systems to a high degree of specificity and regularity. High frequency, accurate, in-situ data is curr ...

In response to NASA SBIR Topic S16.07, ThermAvant Technologies, LLC proposes to develop highnbsp;conductance cryogenic oscillating heat pipes for space applications. Working fluids will be investigated at temperatures between 77 Knbsp;and 230 K. The oscillating heat pipes will be developed in a range of geometries to demonstrate high effective thermal conductivities innbsp;complex 3D geometries an ...

To provide significant improvements in aircraft fuel/energy economy and emissions, electric aircraft are being developed with a current commercial market of $7.9 Billion in 2021 with predicted growth to $27.7 Billion by 2030.nbsp; Per NASA 2020-I SBIR A1.04 Electrified Aircraft Propulsionnbsp;(EAP), thermal management systems (TMS) are needed which can be scaled to high power required to make EAP ...

Mitofusin agonists for the treatment of neurodegenerative diseases Gerald W Dorn II, MD Mitochondria in Motion, Inc. Washington University in St Louis School of Medicine Abstract: A number of rare neurodegenerative diseases are characterized by mitochondrial fragmentation, dysmotility and dysfunction. Among these are Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD), which cause ...