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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ITK TXK Inhibitors as Oral Immunotherapeutic Drugs for Psoriasis

    SBC: CONFLUENCE LIFE SCIENCES, INC.            Topic: NIAMS

    Psoriasis is a devastating autoimmune disease that manifests itself in the form of patchy inflammatory skin lesions that can appear anywhere throughout the body resulting in tremendous physical pain and discomfort This chronic disease can also cause arthritic joints and have a profound impact on a patient s psychological well being In psoriatic lesions the detection of increased numbers of T c ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. ErythroMer Nanoscale Bio Synthetic Red Cell Substitute

    SBC: Kalocyte Inc            Topic: NHLBI

    PROJECT SUMMARY There is need for an artificial oxygen O carrier to substitute for banked blood in settings where stored blood is unavailable pre hospital care transport austere environments undeveloped countries or undesirable transfusion risk exceeds benefit To address this need we developed ErythroMer EM a first in class nano cyte blood substitute EM is a deformable ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Epigenetic fingerprinting of label free DNA using a solid state nanopore

    SBC: Esper Biosciences Inc            Topic: 172

    Project Summary In an effort to improve the scientific and medical communities ability to access epigenetic information this project aims to develop a label free method to detect epigenetically modified bases in DNA The method that will be developed relies on the use of a carbon nanotube charge sensor integrated with a solid state nanopore DNA will be driven through the nanopore by electropho ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. CDK inhibitor for the treatment of HER breast cancer

    SBC: SENEX BIOTECHNOLOGY, INC.            Topic: 102

    Approximately of breast cancers overexpress oncogenic tyrosine kinase receptor HER NEU Patients with metastatic HER cancer typically receive HER targeting monoclonal antibodies trastuzumab and pertuzumab often combined with a taxane a small molecule HER inhibitor lapatinib or a HER specific antibody drug conjugate T DM are used in later arms of treatment Despite the transformative ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Nature inspired methods for long term banking of endocrine cells within encapsulation devices

    SBC: Sylvatica Biotech, Inc.            Topic: 200

    Project Summary The objective of this study is to investigate and develop long term storage of cells using cryopreservation in the context of improving health of islets for islet transplantation as a Type Diabetes treatment The goal is to develop a high subzero cryopreservation method that cools cells inside protective immunoisolation devices to extend preservation time to weeks and months Our ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A High School Program for Preventing Prescription Drug Abuse

    SBC: NATIONAL HEALTH PROMOTION ASSOCIATES, INC            Topic: NIDA

    ABSTRACT A High School Program for Preventing Prescription Drug Abuse This Fast Track SBIR proposal is designed to address the critical need for an effective primary prevention approach for prescription drug abuse PDA an urgent public health crisis in the United States Deaths from prescription drug overdoses have more than tripled in the past years and the abuse of prescription opioids has ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Cardiac Monitor for VA ECMO Pediatric and Neonatal Patients

    SBC: TRANSONIC SYSTEMS, INC.            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT Venoarterial Extracorporeal Membrane Oxygenation VA ECMO is a way to provide cardiac and pulmonary support to patients without other alternatives This form of life support is vital to pediatric and neonatal patients As with any life support there are serious complications that occur These complications including bleeding thrombosis and infection become more frequen ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A novel product for tendinopathy treatment

    SBC: NEW YORK R&D CENTER FOR TRANSLATIONAL MEDICINE AND THERAPEUTICS, INC.            Topic: NIA

    Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Microfabrication based Biomimetic Approach for In Vitro Red Blood Cell Maturation

    SBC: Simpore Inc.            Topic: NHLBI

    Abstract The overall goal of this proposal is to develop systems for efficient ex vivo maturation of functional human red blood cells RBCs which holds tremendous potential for addressing supply bottlenecks for delivering new therapeutic options to chronically transfused patients with severe alloimmunization and for novel strategies for delivering therapeutics via engineered RBCs No approaches ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Structure based optimization of a novel pharmacological chaperone therapy for MPSIIIC

    SBC: Phoenix Nest Inc.            Topic: NICHD

    PROJECT SUMMARY Lysosomal storage diseases LSD are rare inherited metabolic disorders caused by defects in the cellular catabolic system Mucopolysaccharidosis Type IIIC MPS IIIC or Sanfilippo disease type C is one such LSD that is caused by deficiency of the enzyme heparan sulfate acetyl CoA glucosaminide N acetyltransferase HGSNAT essential for degradation of heparan sulfate a repeati ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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