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DESCRIPTION provided by applicant We propose to use CatAssaysandapos novel Palladium Catalyzed Chemical Amplification PdCCA technology platform to develop ultra sensitive sandwich ELISA format bioassays to detect very low concentrations of a number of critical cancer and immunoregulatory biomarkers CatAssaysandapos PdCCA technology the first example of the application of heterogeneous me ...

DESCRIPTION provided by applicant Lung cancer causes more deaths in men and women than any other cancer in the United States Late detection of disease and inability to effectively treat this malignancy with chemotherapy are the main reasons for low survival rates There is an urgent medical need to develop new molecularly targeted drugs for treating lung cancer although it has been challengin ...

DESCRIPTION provided by applicant The treatment of Esophageal Cancer has experienced a palpable increase in the last few years While numerous options are currently under investigation many if not all remain suboptimal This is critical as it is estimated that in there were new cases and over deaths from esophageal cancer worldwide In the US alone there were new ...

DESCRIPTION provided by applicant The most promising immunotherapies against cancer rely upon modulating CD and various CD T cells to activate against cancers like melanoma lymphoma and leukemia However the ability for researchers to measure the secreted effector proteins per heterogeneous T cell which determine the cellular potency against the cancer is limited today This Phase ...

DESCRIPTION provided by applicant In rheumatoid arthritis dysregulation of both the adaptive T and B cells and the innate dendritic cells macrophages neutrophils immune responses result in a complex network of cytokines chemokines and growth factors that initiate and perpetuate the pathogenesis of the disease Vascular endothelial growth factor VEGF is a proangiogenic and proinflamma ...

DESCRIPTION provided by applicant Wound healing is an intricately regulated process broadly characterized by phases of inflammation proliferation and remodeling Imbalances in any one of these phases can result in inadequate healing scar formation or in the development of chronic wounds such as diabetic ulcers Diabetic ulcers are responsible for the majority of lower extremity amputations ...

DESCRIPTION provided by applicant Infrared activated promoter for gene therapy of arthritis It is fair to generalize that unfortunately more patients currently die from toxicity of medications than from disease Although gene therapy is a promising alternative to small molecule drugs allowing to produce biologics inside the body and to reduce costs of treatment its progress has been stalled d ...

DESCRIPTION provided by applicant ReVivo Medical LLC has developed the next generation of spinal fusion implants to help surgeons and hospitals achieve the goals of the Affordable Care Act ReVivoandapos s spinal implants are the first to leverage the basic science of bone formation to reduce time to fusion while also diminishing complication rates decreasing operating room time and loweri ...

DESCRIPTION provided by applicant Air quality affects the health and well being of each of us especially those with chronic respiratory diseases Acute exposure to fatal levels of hazard materials causes millions of accidents every year and unnoticed long term exposure to lower levels of chemicals affect far more people Various technologies have been developed to monitor air quality but no ...

DESCRIPTION provided by applicant Colorectal cancer CRC is the second most common cause of cancer death in the US causing more than deaths each year Unfortunately African Americans AAs experience disproportionate incidence and mortality rates of CRC across all races in the US due to a complex interplay of economic social and cultural factors AAandapos s higher incidence lower r ...