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SBC: Pharmareview Corporation Topic: 101
DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with the highest mortality rate of all stroke subtypes ICH is one of the leading causes of long term disability Since there are no available FDA approved therapies for ICH it is of vast importance to search for new approaches in treatment for this devastating medical condition Lactoferrin LT ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: IRIS TECHNOLOGY CORPORATION Topic: MDA17T003
As the orbital space around the earth gets more and more crowded with civilian and military reconnaissance, weather, tracking, communication, and navigation satellites - civilian and military users become increasingly dependent on the services provided by these spacecraft. This situation increases the possibility of offense actions against some or all of these spacecraft. The possibility calls for ...STTR Phase II 2020 Department of DefenseMissile Defense Agency
SBC: DISCOVERYBIOMED, INC. Topic: NIDCD
Principal Investigators for Small Business: DiscoveryBioMed, Inc. (DBM) and Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challenges: food insecurity, poor nutritional health, and poor compliance with medication use, particularly among children and the elderly. Sugar and salt, the mainstays to addres ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
SBC: Arete Associates Topic: N19AT010
The objective of this project is to advance the capabilities of the Coastal Battlefield Reconnaissance and Analysis (COBRA) system by creating a Surf Zone Modelling Tool (SZT) that can create realistic synthetic imagery of the surf zone (SZ). Through the use of this synthetic imagery the COBRA Program will be enabled to inform concept of operations (CONOPS) in unfamiliar environments as well as mo ...STTR Phase II 2020 Department of DefenseNavy
SBC: MAINSTREAM ENGINEERING CORP Topic: MDA18021
Mounting of infrared (IR) windows on hypersonic vehicles is a critical design issue because of the stresses caused by high temperatures combined with the coefficient of thermal expansion (CTE) mismatch between the window and frame materials. Many applications use elastomeric seals to limit window distortion and stress by allowing for joint flexibility. However, windows and frames operating in this ...STTR Phase II 2020 Department of DefenseMissile Defense Agency
SBC: POLARIS SENSOR TECHNOLOGIES INC Topic: AF071340
Because of the maneuvering capabilities of adversaries’ new hypersonic weapons, defensive missiles must fly in very demanding flight regimes, and intercept maneuvers place stringent requirements on interceptor seeker systems. Successfully completing the hit-to-kill end game requires the seeker can either compensate for or perform despite the thermal and optical effects that cause the seeker to m ...STTR Phase II 2020 Department of DefenseMissile Defense Agency
SBC: NeoVative, Inc. Topic: 400
“Code blue” is the signal used in hospitals to call for an immediate cardiopulmonary resuscitation (CPR) following a cardiac or respiratory arrest. Reviewing the performance of the “code blue team” is a cornerstone for improving outcomes. The current standard of using handwritten records on a paper “code sheet” does not allow measurement of key quality indicators and is subject to huma ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Development of Spleen Tyrosine Kinase (SYK) negative allosteric modifiers for therapeutic intervention in Alzheimer's disease.SBC: ARCHER PHARMACEUTICALS, INC. Topic: NIA
Pathological hallmarks of Alzheimerandapos;s disease (AD) include extracellular deposits of Aβ peptides, intraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammation. Most proposed AD disease modifying therapies have focused on strategies that reduce brain Aβ/amyloid or tau pathological accumulation. However, such approaches have been unsuccessful in late stage AD clin ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
SBC: Logistic Gliders Inc. Topic: ST14B004
We propose to mature LG-X glider technology by manufacturing full-scaled prototypes and characterizing them in land-based flight-testing by using commercial aircraft to drop the gliders. Validated components such as the landing parachute, folding wing mechanism, and autopilot control system will undergo integrated flight-testing. Logistic Gliders will provide a considerable cost share to support ...STTR Phase II 2016 Department of DefenseDefense Advanced Research Projects Agency
SBC: Eigen Health Services LLC Topic: 102
Project Summary Prostate cancer is one of the most commonly occurring forms of cancer, accounting for 21% of all cancer in men. The Prostate Imaging Reporting and Data System (PI-RADS) aims to standardize reporting of prostate cancer using multi-parametric magnetic resonance imaging (mpMRI). However, the in-depth analysis, as demanded by PI-RADS, remains challenging due to the complexity and heter ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health