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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel treatment for DIC

    SBC: A2 Therapeutics Inc.            Topic: NHLBI

    Project Summary Several diseasesincluding endotoxemiaand sepsis can cause disseminated intravascular coagulationDICDIC can induce the formation of microvascular thrombicausing organ failure and death in the absence of the appropriate treatmentTo datethere are no drugs to treat DICand several reagents have been tested buttheir strong doses can lead to severe bleedingsignificantly diminishing their ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. System-independent quantitative cardiac CT perfusion

    SBC: BIOINVISION INC            Topic: NHLBI

    System independent quantitative cardiac CT perfusion Summary BioInVisionIncand Case Western Reserve University researchers will develop software for quantitative analysis of cardiac CT perfusionCCTPcreating an important tool for evaluation of cardiovascular diseaseWith this productcardiologists will be able to identify functional flow deficits in coronary artery territoriesWhen one combines functi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development and non-clinical GLP testing of a new anti-arteriosclerosis gene therapy delivered by engineered adeno-associated viral vectors.

    SBC: KIROMIC BIOPHARMA INC            Topic: NHLBI

    AtheroSclerotic CardioVascular DiseaseASCVDis caused by inflammation within arteriesWhite blood cells enter the arterial wallsmacrophages become engorged with lipid cholesterol and summon other inflammatory cells to form plaques which ultimately rupture or occlude the arterykilling down stream tissuee gheart attackASCVD remains a major cause of morbidity and mortality of the elderlyCoronary artery ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A 3D Printed Resorbable Antimicrobial Envelope to Prevent Infection of Implanted Cardiac Devices

    SBC: N8 MEDICAL INC            Topic: NHLBI

    ABSTRACT Infection is a serious and potentially fatal complication of surgery to deliver cardiovascular implantable electronic devicesCIEDsi epacemakers and implantable cardioverter defibrillatorsUntreated device related infection is associated with mortality rates as high asCurrentlyonly one antibiotic impregnated mesh has been FDA approved for placement in surgical incisions to reduce infections ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. In Silico Identification of Novel GHB Receptor Ligands for SSADH Deficiency, a Disorder of GABA Metabolism

    SBC: SPERAGEN, INC.            Topic: 102

    Summary The most prevalent inherited disorder of GABA metabolismsuccinic semialdehyde dehydrogenase deficiencySSADHDpresents a non specific neurological phenotype associated with physiological accumulation of the major inhibitory neurotransmitter GABA and the GABAderivativehydroxybutyrateGHBAn absence of targeted therapy for SSADHD underlies this application s rationalePreclinical and clinical stu ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Non-Metal PN Scavenger/Decomposition Catalysts for Treatment of Migraine

    SBC: CERSCI THERAPEUTICS INCORPORATED            Topic: 102

    Project SummaryAbstract The World Health Organization ranks migraine as therd most prevalent disease worldwide andth most disablingth most in womenmaking it the most common neurological disorderOne of the primary reasons for the disabling nature of migraine is the poor efficacy of currently available therapeuticsLess thanof patients achieve complete relief with acute agents such as triptans and on ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Farnesol as Novel Treatment in Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD)

    SBC: SPERAGEN, INC.            Topic: 102

    SUMMARY Succinic semialdehyde dehydrogenase deficiencySSADHDis a rare neurometabolic disease caused by mutations in the ALDH AgeneThe disorder is associated with significant developmental delay and extensive neurological morbidity including seizuresSeizures increase with agein patients as well as in experimental aldh adeficiencyaldh amicewhere seizures increase in frequency and severity starting a ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain.

    SBC: ASPIREBIO CORP            Topic: 101

    PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Magnetic camera based on optical magnetometer for neuroscience research

    SBC: FieldLine Inc.            Topic: 101

    Abstract During Phase Iwe will test the feasibility of developing a magnetographic camera technology as a new tool in neuroscience to facilitate the detailed analysis of electrical currents in diverse neuronal circuitsInstead of photographic imagesthe camera will produce single shot images of the magnetic fields from in vivo samples of interestsuch as a patch of the grey matter in the cerebral cor ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Cuff Electrodes with Soft Wire Electrical Leads

    SBC: TDA RESEARCH, INC.            Topic: 102

    Project Summary AbstractDevelopment of a Nerve Cuff Electrode from Soft and Elastomeric Conducting Wires STTR Phase I ApplicationPIBrady ClapsaddleTDA ResearchIncBio electronic interfaces are used in a wide array of applications for recording and providing electrical impulses to treat diseaseOne common interface device for the PNS is the cuff electrodeCurrent cuff electrodes have many failure mode ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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