Award Data

This Small Business Technology Transfer (STTR) Phase I project proposes to combine a novel metabolically engineered Chinese hamster ovary (CHO) cell line with a unique, high performance, continuous cell-culture bioreactor to demonstrate the commercial viability of producing a bioengineered heparin from CHO cells. This CHO cell line overexpresses critical enzymes in the heparin biosynthesis pathway ...

This Small Business Technology Transfer (STTR) Phase I project proposes to engineer butanol tolerance in the yeast Saccharomyces cerevisiae using a novel combinatorial genetic technology designed to enable yield enhancements in microbial production organisms. Microbial production of renewable fuels and chemicals is rapidly expanding. However, toxic products or by-products and engrained metabolic f ...

This Small Business Innovation Research Phase I project will scale up high-yield hydrogen production from maltodextrin and water mediated by cell-free enzymatic biosystems and develop prototype mobile electricity generators (MEGs). Cell-free biosystems for biomanufacturing (CFB2) implement complicated biochemical reactions in one pot by the in vitro assembly of more than three enzymes and/or cofac ...

This Small Business Technology Transfer (STTR) Phase I project proposes to establish cost effective methodologies for the efficient production of catechins utilizing a microbial fermentation approach. Preliminary work on the biosynthesis of the catechins, using metabolically engineered Escherichia coli recombinant strains from their flavanone and phenylpropanoid acid precursors, has demonstrated f ...

This Small Business Technology Transfer (STTR) Phase II project proposes the development of an integrated powered knee-ankle prosthesis. The objective of this proposal is to investigate the use of integrated powered knee and ankle joints in trans-femoral prostheses that use sensory information from the ground and the wearer. The hypothesis is that a prosthesis with actively powered knee and ankle ...

This Small Business Technology Transfer Phase I project will develop a new system for fabrication and manipulation of carbon nanotube (CNT) composites. The system will use holographic optical trapping (HOT) with a spatial light modulator (SLM) and a new form of nano-controlled photo-polymerization. This tool will allow the creation of a new class of carbon-nanotube polymer composite materials wit ...

This Small Business Technology Transfer (STTR) Phase I project aims to develop a manufacturing process that can coat a variety of substrates with uniform thin films of inherently conducting polymer (ICP) nanofibers over a large area. Traditionally, these nanostructured organic materials are difficult to process into thin films covering a large area, which has limited the commercial applicability ...

This STTR Phase I project proposes to develop and establish a novel clumping (flocculation) strain of algal using an engineered extracellar protein that can be induced. The overarching goal is to provide the industry with a novel, energy efficient, and cost effective tool to dewater microalgae. What are the broader/commercial impacts of the proposed project? The broader/commercial impact of the p ...

This Small Business Technology Transfer Phase I project will address the critical need for low driving voltage, adaptive materials providing large phase retardation (for ultraviolet, visible, and infrared wavelengths) within a sub-millisecond time frame. Two technologically innovative tasks will be pursued in parallel and then merged, resulting in the creation of a new class of optical materials - ...

This Small Business Technology Transfer (STTR) Phase I project aims to develop roll-to-roll processing of highly efficient, thin film photovoltaics on inexpensive polycrystalline substrates. The innovation lies in an architecture that yields near-single-crystalline thin films even on polycrystalline substrates. This innovation will be combined with the benefits of hot wire chemical vapor deposit ...