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SBC: Science Take-Out, LLC Topic: R
ABSTRACT This supplement project will expand on our current STTR Phase I project in which we partnered with University of Rochesterandapos;s Environmental Health Sciences Center to develop three Science Take-Out vaping education kits. Our vaping education kits involve students in using hands-on activities and real-life scenarios to investigate the harmful effects of chemicals used in e-cigarette f ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Lacerta Therapeutics, Inc. Topic: 102
Glioblastoma (GBM) is the most lethal form of adult brain cancers with a median survival of andlt;15 months despite aggressive standard chemoradiation. GBM are formed by GBM stem-like cells (GSCs) - a major contributor to tumor recurrence and a natural focus for therapeutic development. There are two main reasons responsible for treatment failure: 1) high intra- and inter-tumor cellular and molecu ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Cetya Therapeutics, Inc. Topic: NHLBI
PROJECT SUMMARY The β-hemoglobinopathies are prevalent genetic blood diseases with few treatment options. It is estimate that 7% of the worldandapos;s population carries an abnormal hemoglobin gene with 400,000 infants born annually with a severe life threatening hemoglobinopathy. Drug mediated induction of normal, but developmentally silenced, fetal hemoglobin (HbF) expression reduces anemia and ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: BERTEC CORP Topic: NIA
Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological,sensory, and motor changes that lead to increased fall risk often escape early identification and intervention. Vital signs are commonly used in clinical settings to assess the cardiovascular system (blood pressure, heart rate), immune system (body temperature), and the respiratory system ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: NUTRONICS, INC. Topic: AF18AT006
Through the execution of our Phase 1 effort, Nutronics, Inc. and Montana State University developed an improved means to optimize the Pellizzarri cost functional for coherent imaging using digital holography. Our algorithm developed during the Phase 1 effort accelerates convergence times by a factor of 20-40 for the majority of scenarios evaluated. Our proposed Phase 2 effort has a two-fold focus: ...STTR Phase II 2019 Department of DefenseAir Force
SBC: ARCTOS Technology Solutions, LLC Topic: DLA18A001
This Phase II project aims to assemble the key set of sensor modalities that are needed to reliably view the key process anomalies and properties of laser powder bed fusion. The research team will down-select from the Phase I sensors investigated and integrate the sensors into a sensor fusion software package that facilitates data collection and synchronization, and eventually feedback control of ...STTR Phase II 2019 Department of DefenseDefense Logistics Agency
Fidelity Enhancement of Nuclear Power Plant Simulators Utilizing High Fidelity Simulation PredictionsSBC: WESTERN SERVICES CORPORATION Topic: 30c
Accurate simulation of nuclear power plant behavior is necessary for both engineering and training applications. An engineering grade simulator, used for design, safety analysis and operations, is characterized by high fidelity, computational power, lack of real-time capability, and user non-interactive environment. By contrast, a training grade simulator, used for operator training and education, ...STTR Phase II 2019 Department of Energy
Novel Home-Based and Low-Cost ECG Device for periodic evaluation of the presence of atrial fibrillationSBC: Global Instrumentation, LLC Topic: 600
Abstract Atrial fibrillation (AF) prevalence is estimated to 1% of the general population in the United States. A shocking 30% to 60% (according to studies) of patients with AF are unaware of their diagnosis (silent AF). Most AF patients will suffer from congestive heart failure or/and develop thromboembolic events leading to a dramatic reduction of patients’ quality of life, and a significant c ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Extending WAAVES+: An animal and environment-agnostic, automated USV scoring platform for high-throughput social, behavioral, and neuropharmacological studiesSBC: CORNERSTONE RESEARCH GROUP INC Topic: 101
Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: AMERICAN TECHNICAL COATINGS, INC. Topic: AF18AT013
Successful completion of this Phase II proposal will fully characterize and evaluate a material for use in RF windows on hypersonic flight vehicles. Phase II will specifically examine the materials suitability through RF testing in X, Ku, and Ka bands and at elevated temperatures to 2000Â°F. The desired outcome will be a material with predictable, repeatable dielectric properties over frequency ...STTR Phase II 2019 Department of DefenseAir Force