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Estimation of the primary parameters like IC 50 in traditional dose-response modelsmay fail or lead to misleading results when the observations are non-onotonic due to drugresistance or virus mutation in various biomedical lab research. The objective of this project isto develop a novel approach to assess dose response relationship, which is applicable to generalpharmacologic, toxicologic, or othe ...

Rodents serve as models for the human brain and behavior, and their calls give researchers a window into their mood. Unfortunately, rodent calls are ultrasonic, so a researcher must record a test and then play the audio back at a slower speed to manually categorize and count calls. Software does exist to accomplish this task, but it does not have the ease of use or accuracy that researchers want. ...

Ultrasonic vocalizations (USVs) provide an excellent behavioral measure that can be used to understand the effects of traumatic stressors on behavior and can be used to screen and identify therapeutic treatments. This provides a strong justification for the use of rodent USVs as a model for emotional processing in PTSD. Since there are no commercially available USV assessment software programs tha ...

Inhalation injury is an important cause of morbidity and mortality in both military personnel and the civilian population. Bronchoscopy, currently the gold standard for assessment of inhalation injury, fails to provide submucosal and functional tissue information, both of which are essential for improved prognostic information. Physical Sciences Inc., in collaboration with University of North Caro ...

Airway compromise is the third leading cause of potentially preventable death on the battlefield.Current evaluation techniques of the airways associated with smoke inhalation injury are highly subjective and lack the sensitivity required of an accurate diagnostic and assessment tool.The problem of detection is further compounded by the late onset of symptoms that in many cases do not present until ...

Current prosthetic feet produce much less peak mechanical power than the able-bodied foot/ankle and release only about half of the mechanical energy generated during gait.This leads to higher energy expenditure among amputees as compared to able-bodied individuals.In addition, the lack of prosthetic ankle range of motion negatively impacts users abilities to navigate slopes and uneven terrain.Ther ...

Accurate assessment of burn depth and surface area are important to clinical decision-making regarding treatment. Initial assessment determines fluid requirements and transportation decisions to distant-care facilities. The clinician must determine if the wound will heal itself or whether excision and grafting are necessary for optimal wound healing. The standard of care remains visual inspection ...

Design Interactive Inc. (DI) and Eastern Virginia Medical School (EVMS) propose to develop an Augmented reality Learning Environment for Refresher Training (ALERT) that provides realistic and relevant Tactical Combat Casualty Care (TC3) scenarios using AR technologies integrated with mannequins for pre-deployment training and humans for deployed training environments. ALERT will facilitate learnin ...