Award Data

DESCRIPTION (provided by applicant): ActivX Biosciences (ActivX) will develop and validate a novel toxicoproteomics platform to correlate changes in protein activity with compound toxicology. This platform uses fluorescent chemical probes to interrogate catalytically active proteins related by super-family derived from any biological sample. Alterations in protein activity are expected to be mor ...

DESCRIPTION (provided by applicant): Physical models of proteins have been proven useful in science classrooms at the high school, undergraduate and graduate levels. These models become discovery tools in the hands of students, turning the abstract concepts of molecular structure and function into something real. Unfortunately, the current method of producing these models, by rapid prototyping in ...

DESCRIPTION (provided by applicant): Innovations in battery technology and microelectronics are now finding wide acceptance in the design of new prosthetic and orthotic appliances, while the actuators used to produce motion and force in these devices remain essentially unimproved. The overall goal of this multi-phase, expanded SBIR project is to adapt a new class of "active" materials--developed t ...

DESCRIPTION (provided by applicant): According to the U.S. Bureau of the Census, approximately 7.7 million people over the age of 15 report they are unable to lift or carry even 10 pounds with their arms because of neuromuscular impairments. Extensive research suggests that "powered orthoses" could provide great benefit to many of these individuals. Comprised essentially of an orthotic brace fitt ...

DESCRIPTION (provided by applicant): Adenosine is an endogenous nucleoside that exerts its physiological effects through four G-protein coupled receptors A1, A2A, A2B, and A3. Adenosine Therapeutics, LLC is interested in the anti-inflammatory actions mediated by the A2A receptor subtype. A lead compound, ATL-146e, is being developed for coronary artery imaging and has also been shown to be effi ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Although weight loss is the most effective treatment for type 2 diabetes, current methods for reducing weight typically are insufficient for long-term weight loss. The mission of AdipoGenix, Inc. is to discover, develop and license novel the ...

DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Existing drug and dietary treatments for obesity are only modestly effective. An approach that is very likely to be effective in treating obesity and with a good side effect profile is a drug that acts directly on lipid metabolism in the fat ...

DESCRIPTION (provided by applicant): The primary purpose of the proposed research is to develop, validate, implement, and norm a practical binaural assessment protocol that can be used clinically with bilateral cochlear implant patients. The protocol will be implemented in a computerized instrument to be developed in the course of the project. Binaural assessment of a cochlear implant patient will ...

DESCRIPTION (Applicant's abstract): The proposed research evaluates the efficacy of the Alertness Profiling (AP) System as a method for objectively quantifying alertness in Sleep Apnea (SA) patients. The AP simultaneously measures electroencephalographic (EEG) indices and performance during vigilance, attention and memory tests. Combining EED and neurobehavioral assessment in a one-hour session, t ...

DESCRIPTION (provided by applicant): The Apnea Risk Evaluation System (ARES) is an inexpensive, in-home method assessing for sleep-disordered breathing. ARES utilizes expert software to integrate analysis of nocturnal oxygen saturation, pulse rate, snoring sounds, head position/movement recordings acquired with a self-applied, portable single-site (forehead) device with analysis of responses to a ...