Award Data

PROJECT SUMMARY ABSTRACT The opioid fentanyl is administered in millions of procedural sedations every yearIt is very potenthas large interpatient pharmacokinetic variabilityand routinely causes significant respiratory depression if bolused or not titrated judiciouslyDosing and timingcritical for safety and efficacyare presently only possible based on educated guesses and vital signsSedation assoc ...

ABSTRACTOtitis media or middle ear infections is a prevalent disease associated with early childhoodThe primary surgical intervention for persistent and recurring otitis media is insertion of ear tubestympanostomymyringotomy tubesThere are aboutear tubes placed annually in the United StatesA recognized risk with ear tubes is secondary infection or post operative otorrheaThe rate of secondary infec ...

PROJECT SUMMARYAcute lymphoblastic leukemia (ALL) and neuroblastoma (NB) are the most common cancers in children. Currently treatment options are often associated with severe side effects. Therefore, there is a strong unmet medical need to develop targeted-drugs with higher therapeutic indexes for improved treatment outcome.The oncoproteins MDM2 and XIAP are important cell-survival proteins in tum ...

Abstract. Melanoma is the third most common form of skin cancer with estimated 87,110 new cases diagnosed in the United States in the year 2017. Current routine diagnostic approaches utilize microscopic evaluation of thinly sectioned patient biopsies, but in certain cases diagnosis can be contentious even among experts. The overall goal of this multi-phase SBIR project is to develop, validate, and ...

Project Summary/Abstract: The objective of this proposal is to create a new surgical device that provides dexterity at the tip of a rigid bronchoscope. Our new system will deliver needle-sized, tentacle-like arms through the bronchoscope port, enabling independent tissue manipulation, laser fiber aiming, and visualization, which we hypothesize will make central airway obstruction surgery safer, m ...

PROJECT SUMMARY ABSTRACT Research has suggested that there is an increased risk of cancer associated with long term exposure to drinking water containing halogenated disinfection by productsDBPsTrihalomethanesTHMsare the most common class of halogenated DBPs formed during water chlorinationEvery yearthousands of drinking water treatment plantsWTPsstruggle with THMs compliance issues often allocati ...

PROJECT SUMMARY / ABSTRACT - STREAM DX Lower urinary tract symptoms (LUTS) is one of the most common medical problems among older men – affecting 33% of men by the time they reach 50 years of age and 75% by the time they reach the age of 80. LUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of life. Early detection, intervention ...

Abstract Chronic phantom limb painPLPhas been reported to inflict as many asof people with amputationsPLP is described as feeling like burningtwistingitchingor pressure in part of the missing limbThese painful sensations have a substantial negative impact on quality of lifepeople who suffer PLP have high rates of depressiondifficulty sleepingregular absences from workdissociation with family frien ...

Seventeen million people each year suffer from an ischemic stroke and millions are left dead and disabledTreatment with recombinant tissue plasminogen activatorr tPAis only modestly effective at reducing disability and it is associated with brain hemorrhage in up toof patients when serial imaging studies are performedBrain hemorrhage causes death and disability andis the major cause of early morta ...

Abstract We propose to build a hermetically sealed implantable stimulation and recording system to enable closed loop experiments while mitigating the need for percutaneous leadsThe IRISImplantable Recording with Integrated Stimulationis a fully implantable system capable of both stimulating and recording on large numbers of channelschannelsOur implantable technology will provide primate researche ...