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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Clinical mass spectrometry test for apolipoprotein C-III proteoforms

    SBC: ISOFORMIX INC.            Topic: 400

    PROJECT SUMMARY Only about dozen mass spectrometryMSprotein tests have been translated into clinical laboratories since the MALDI and ESI approaches were developed thirty years agoWhile the cost and complexity of these tests are important factors impeding their clinical adoptionnew content generated via proteoforms detection could provide the impetus for further development and translationOur rece ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Microbiome Meta-Analysis Platform

    SBC: INFOTECH SOFT, INC.            Topic: 400

    Researchers from very diverse fields are expanding their research to microbiome studies to understand the interactions between microbes, hosts, and the environment. As new technologies for accelerated production of microbiome sequence data have enabled this type of research, there is a pressing need for high performance computation resources that accommodate flexible and consistent configuration, ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Measuring Infant Pain Objectively using Sensor Fusion and Machine Learning Algorithms

    SBC: AUTONOMOUS HEALTHCARE INC            Topic: R41

    Newborns are routinely and frequently exposed to pain during Neonatal ICUNICUcarePain assessments in neonates are difficultlabor intensivesubjective and unreliableoften resulting in excessive or inadequate analgesiaOur overall objective is to measure infant pain objectivelyreliablyand in real timeWe will extract pain related information from multiple non invasive sensorsdevelop a sensor fusion fra ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. I-Corps Supplement to parent grant DNA Encoded Macrocycles Libraries As A Source of Protein-Protein Interaction Inhibitors

    SBC: DELUGE BIOTECHNOLOGIES INC            Topic: 300

    Project Summary Protein protein interactionsPPIsare at the heart of almost every biological processThereforethere is great interest in the discovery of chemical probes that potently and selectively antagonize PPIsThis generally requires chemical matter quite different than the Lipinski compliant small molecules typically employed to antagonize enzyme active sitesThis project will create a novel li ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Cell-free protein synthesis (CFPS) devices with high-yield for synthetic biology

    SBC: DASFANH BIOSCIENCES, LLC            Topic: 400

    Project SummaryCell free protein synthesisCFPSis a method of producing proteins outside living cells and has distinct advantages over traditional cell culture based protein productionIt is often difficult to maintain complex environmental condition for cell viability and the subsequent need to develop a downstream process for purification of product in traditional cell based systemsCFPSon the othe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Development of an Oral WNT inhibitor

    SBC: Stemsynergy Therapeutic            Topic: 102

    ABSTRACT Colorectal cancerCRCrepresents the fourth most commonly diagnosed cancer withnew cases each yearUnfortunatelyCRC results in a disproportionate number of deathsprojected indue to advanced stage at diagnosisthe aggressive phenotype of the disease and lack of effective therapeuticsGreater thanof CRC patients possess activating mutations in the WNT signaling pathwayWNT pathway activation is a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Tools and Methods for Producing High Quality Functional Protein Microarrays for Biomarker Discovery

    SBC: SPOC PROTEOMICS INC.            Topic: 100

    Abstract ProjectAdministrative Supplements to projectTools and Methods for Producing HighQuality Functional Protein Microarrays for Biomarker Discovery INanoBio is developing ProCap system capable of semi automated production of functional protein arrayswhich can be phosphorylatedde phosphorylated by kinasesphosphatases in high throughput formatin addition to other PTM modificationsAs described in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. HLS-Development of a cardiac ischemia model in an organ-on-a-chip platform

    SBC: HESPEROS, INC            Topic: NHLBI

    Project SummaryFor HLSour overall strategy for Hesperos is to utilize microphysiological systems in combination with functional readouts to establish platforms capable of sophisticated analysis of chemicals and drug candidates for toxicity and efficacy during pre clinical testingwith initial emphasis on predictive toxicityThis is a service based company and is developing low cost in vitro systems ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Human on a chip system to investigate genetic risk factors in Alzheimer's disease

    SBC: HESPEROS, INC            Topic: NIA

    Project Summary AbstractHesperos will construct and test microscale multi organ systems with recirculating blood and cerebral spinal fluid surrogates that will give insights to the responses of various Alzheimer s phenotypes to drugs as well as the influence of peripheral effects on AD progressionspecifically ApoE variantsWe seek to leverage DrMorgan s research on Alzheimer s and aging combine it ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders.

    SBC: MYOLEX, INC.            Topic: NINDS

    Project SummaryTo improve the efficiencyconvenience and quality of ALS clinical trialswe need better biomarkers for assessing amyotrophic lateral sclerosisALSprogression and response to therapyAll recent ALS trials require patients to visit an ALS clinical trials center everymonths at which time assessments are obtainedincluding limb strengthvital capacityand the ALS functional rating scale revise ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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