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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. FilmArray-A Closed System for Multi-Pathogen Screening

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Polymerase chain reaction (PCR) has become the method of choice for rapid diagnosis of infectious agents. To identify an infectious agent by molecular means requires a panel of PCR assays. So called "multiplex PCR" concurrently assays for multiple targets in a single reaction. Multiplex PCR has proved valuable in some systems, but shortcomings exist concerning ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. A System for Rapid PCR, Mutation Scanning and Genotyping

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to provide a closed-tube system for rapid PCR, mutation scanning and genotyping that does not require fluorescently-labeled probes. For many genetic diseases, it is difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution for rapid amplification, scanning and genotyping in ...

    STTR Phase I 2005 Department of Health and Human Services
  3. A System for Rapid PCR, Mutation Scanning and Genotyping

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to provide a closed-tube system for rapid PCR, mutation scanning and genotyping that does not require fluorescently-labeled probes. For many genetic diseases, it is difficult and expensive to screen for all possible mutations that may cause the disease. We propose a relatively simple solution for rapid amplification, scanning and genotyping in ...

    STTR Phase II 2005 Department of Health and Human Services
  4. Genotype Analysis for Diagnosis of Urea Cycle Disorders

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Urea Cycle Disorders (UCDs) are metabolic diseases disrupting ureagenesis. Unequivocal and rapid diagnosis of UCDs is difficult because hyperammonemia, the primary biochemical phenotype, is not specific to UCDs being observed in broad categories of metabolic deficiencies including fatty acid oxidation defects, lactic acidosis, and organic acidemias. Clinical p ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Quantitative RT-PCR: Prediction Lymphoma Transformation

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Completion of the human genome and the advent of expression profiling have permitted comprehensive characterization of the transcriptional signatures of different disease states. Quantitative fluorescent real-time polymerase chain reaction-based methods have emerged as a powerful tool in molecular diagnostics as they combine extraordinary dynamic range of quant ...

    STTR Phase I 2005 Department of Health and Human Services
  6. System for Non-Invasive EMG Motor Unit Recording

    SBC: RIPPLE, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this program is to create a clinical system for non-invasively recording EMG motor unit signals. This system will use Blind Source Deconvolution (BSD) signal processing techniques to collect these signals with surface electrode arrays, rather than needle electrodes that must be inserted and manipulated by highly trained clinicians. This system will ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. NON-IRRITATING RETINOIDS FOR THE TREATMENT OF AGING

    SBC: MOLECULAR DESIGN INTERNATIONAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This application represents the Phase II version of SBIR grant R43 AR049621 entitled "Non-Irritating Retinoids for the Treatment of Aging Skin". Studies carried out prior to Phase I and during the Phase I portion of this project have demonstrated that a synthetic retinoid (identified as MDI-301) is as effective as all-trans retinoic acid (RA) in stimulating col ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Electric Heavy-Duty Work Hand

    SBC: MOTION CONTROL, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Specific Aims: Motion Control Inc. proposes to develop two new rugged, electric terminal devices (IDs) for heavy-duty work activities, both based upon the same rugged drive and motor. These IDs will be: the Work Hand and the Work Hook. These new terminal devices will be lighter in weight, can be used in more extreme environments, and will offer more versatile g ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. Recombinant IalphaIp: Treatment for Sepsis

    SBC: MULTICELL TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sepsis is the systematic and overwhelming response to infection. Once triggered, an uncontrolled cascade of coagulation, impaired fibrinolysis, and inflammation drive disease progression. This results in damage to the lungs, liver, kidney and cardiovascular system, leading to multiple organ failure and an associated high mortality rate in severe sepsis disease ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Open Architecture Image-Guided Therapy Software System

    SBC: PATHFINDER THERAPEUTICS            Topic: N/A

    DESCRIPTION (provided by applicant): One of the important developments in disease treatment over the past decade has been the development of image-guided procedures. The rise of such systems has also been associated with a contraction of the market with a few companies becoming the dominant players in the field. In such a contracted commercial state, the field does not rapidly expand but rather ha ...

    SBIR Phase I 2005 Department of Health and Human Services

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