Award Data

We will develop a strong, safe, easy-to-use, biocompatible, and degradable bioadhesive for surgicalrequiring tissue sealing and closure. This bioadhesive will have the potential to streamline commonwell as provide new technology in areas such as organ hemostasis. The following specific aims will agoal: 1) optimize the formulation of the bioadhesive and develop a delivery device; 2) evaluate thetox ...

Although the autogenous saphenous vein is the vessel typically utilized in arterial bypass procedurarise in which it is not possible to use this vein, demanding an alternative method. The investigatofeasibility study in canine subjects to determine whether an immunologically modified xenogeneic vesendothelium can serve as a replacement of the autogenous saphenous vein. The investigators intend tot ...

Autologous patellar tendon grafts are the current gold standard for replacement of irreparable anteligaments. Allogeneic tissue grafts are the only accepted alternative to autologous grafts and theysupply. We will develop a non-immunogenic bovine fascia lata as a graft material for anterior cruciagrafts will be rendered non-immunogenic by in vitro processing. The resulting collagen tissue matrixbi ...

Due to rapid advances in client/server technology, software applications running on microcomputersmanage complex data residing in distributed databases. We will develop a truly user-friendly databasthe management of objective psychological test data that will run identically on IBM PC/PC clones orcomputers and access data stored on several different platforms. The project will feature five coreman ...

This project is designed to satisfy the need for a new generation of accurate and non-invasive bloodevices with multi-analyte, multi-signal capability. Phase I will demonstrate the feasibility of a bnon-invasive and simultaneous detection of oxy-hemoglobin, deoxy- or reduced hemoglobin, carboxy-hemhemoglobin in arterial blood. The breadboard will be based on the differential absorption and multipt ...

Adenosine produces coronary vasodilation through activation of A-2a adenosine receptors. However adalso acts at A1 adenosine receptors to slow atrioventricular conduction and when injected into man ican be blocked with A1 receptor antagonists. DTI has synthesized a number of adenosine analogs that2a subtype of adenosine receptor and have identified WRC-0470 as a potent selective short acting corou ...

This project is to design develop and test a culturally sensitive computer- interactive program forstyle, health, and dietary practices of African American women. The "Afro-SISTER" Program is the acrAfro-Sensitive Information System To Evaluate Risk" (SISTER) of nutrition-related diseases. The progprompted on a touch-sensitive computer screen. It will display culturally relevant activities, ethnil ...

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Dramatic extensions of a recently-demonstrated, electro-optic, radiated- RF-field probe concept areallow RF field measurements in RF hyperthermia therapy and other important health-related applicatiomethod employs optical-phase-modulating transducers to measure the amplitudes of single RF field vecsignificant innovations will allow the development of an all-dielectric probe small enough and nonpeu ...