Award Data

ABSTRACT The goal of this Uproposal is to develop and test CranialProgrammeran image guided programming tool forDD mapping of disease related neural signals over patient and device data for more efficient and effective programming of directional deep brain stimulationDBSsystemsDBS is an established treatment for advancedrefractory movement disorders used in overpatientsHowevermany patients receive ...

PROJECT SUMMARY There are aroundemergency room admissions annually in the US due to scuba injuriesFrom thosearoundrelate to Decompression SicknessDCSa condition developed when nitrogen dissolved in blood and tissues at high pressure forms bubbles as pressure decreasesTreatment for DCS is recompression in hyperbaric chambersfollowing slow and controlled normalization of pressure conditionsEarly int ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to enable the development of a unique wearable scuba-diving device that will eliminate the risk of Decompression Sickness (DCS), by monitoring in real time the formation of nitrogen bubbles in the body of the user while in the dive. The risk to develop DCS while conducting underwater activi ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be realized first in pharmaceutical manufacturing where powder blends are needed to make tablets. These tablets constitute 40% of the most profitable pharmaceutical products, and nearly 80% of commercial products. The proposed device (sampler) will protect employees in pharmaceutical plan ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will address ALL of the factors attributing to protein aggregation by determining the: size, identity, extent, mechanism of aggregation and stability, thus addressing Biopharma industry needs. This information is critical to the development of drug pipeline contributing to a $190 BN biologic' ...

ABSTRACT Endometriosis is a highly prevalent gynecologic disease characterized by severe pelvic pain and infertility that negatively impacts the wellbeing and quality of life of millions of women worldwide Despite decades of basic and clinical research on endometriosis there is limited understanding of its pathophysiology and no specific non invasive diagnostic assays are available ...

Project Summary Antibodies can facilitate the study of associations between different proteins in the cell using a technique known as immunoprecipitation IP This approach can reveal differences in protein associations present in healthy vs diseased tissues provide targets for diagnostics and therapeutics and reveal protein protein interfaces that could be druggab ...

Broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to (1) improve the decision making towards protein therapeutics development (also known as developability), (2) reduce Research and Development costs for the Biotechnology industry in general, (3) improve timelines of new protein therapeutic candidates, thus proceeding to clinical phase trials ...

This Small Business Innovation Research (SBIR) Phase I project will develop prototype MgB2 wires for next generation cryogen-free 1.5 Tesla (T) and 3.0 T magnetic resonance imaging (MRI) systems, by adding both magnetic and nonmagnetic impurities. These impurities will amplify the vortex pinning due to magnetic impurities, while compensating the concomitant magnetic impurity-induced transition tem ...

This Small Business Innovation Research (SBIR) Phase I project is designed to develop a vaccine to prevent infection of dairy and beef cattle with Babesia organisms following bites of vector Boophilus ticks. There is currently no killed vaccine that prevents initial infection with Babesia organisms when cattle are bitten by Babesia-carrying ticks, nor reduce levels of infection with Babesiais is b ...