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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Nano-Oscillator Arrays for Sensitive Plasmonic Detection of Molecular Interactions and Reactions

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    ABSTRACT Detecting molecular interactions and reactions are basic tasks to understand biochemical processes in living organismsdiscover biomarkers and develop drugsTodayandapos s mainstream commercial detection technologies are based on measuring mass changeswhich struggle to detect small moleculese gmetaboliteshormonesand neurotransmittersand biochemical reactions involving small mass changese gp ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Lab-To-Marketplace: Commercialization of a stretchable microelectrode array

    SBC: BMSEED LLC            Topic: NINDS

    Project Summary Abstract The proposed work is directed at the commercialization of BMSEEDandapos s Micro Electrode Array Stretching Stimulating und Recording EquipmentMEASSuREtechnologyMEASSuRE bridges the gap between in vitro and in vivo research by simulating the biomechanical and electrical environment of cells in the body in a controlled environment outside of the bodyThe applications for MEAS ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Combining Next-Generation Sequencing and Advanced Algorithms to Elucidate Tumor Heterogeneity

    SBC: Medley Genomics            Topic: 100

    PROJECT SUMMARY Cancer is one of the leading causes of morbidity and mortality worldwideDriven by advancements in quantifying and characterizing the molecular profile of the tumorcancer therapy is becoming more personalizedselectiveand specificA key factor contributing to the lethalitytherapeutic failureand drug resistance of cancer patientshoweveris intra tumor heterogeneityITHcharacterized by a ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. GAA-ITEM: Personalizing the Prediction of Anti-therapeutic Antibody Response in Pompe Disease Patients

    SBC: EPIVAX, INC.            Topic: 999

    Abstract SignificanceInfantile Pompe DiseaseIPDis an autosomal recessive glycogen storage disorder caused by a deficiency of acid alpha glucosidaseGAAleading to accumulation of glycogen in lysosomesprimarily in skeletalcardiac and smooth musclesUntreated IPD infants die within the firstyears of lifeEnzyme replacement therapyERTwith recombinant human GAArhGAAimproves survival and quality of lifebut ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Novel method for spatial, multi-omicvisualization of single-cell heterogeneity

    SBC: BIOSYNTAGMA, LLC            Topic: 100

    Project SummaryThe ability to understand and measure heterogeneity is necessary in order to make advances in fighting diseases like Alzheimerandapos sdiabetesand cancerThe ability to elucidate the differences between cell types and their locations within a tissue would provide insight into how cells interact with each other and the mechanisms that give rise to various disease statesand would help ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Intelligent Power Source Reliability Monitoring and Failure Mitigation System

    SBC: Alphacore, Inc.            Topic: T3

    Alphacore Inc. will develop a high-accuracy built-in self-test (BIST) system for characterization of aging, degradation, available power and in-situ diagnosis of photovoltaic and multi-pack battery systems using low-complexity single-chip impedance spectroscopy (IS) approach. Alphacore will collaborate with Arizona State University (ASU) scientists to develop a low complexity single-chip photovolt ...

    STTR Phase I 2018 National Aeronautics and Space Administration
  7. Bio-inspired Cellular Material Optimization for the Design of Additively Manufactured Multi-Functional Lightweight Structures

    SBC: Phoenix Analysis and Design Technologies, Inc.            Topic: T3

    New technologies in imaging and manufacturing, including Additive Manufacturing (AM), are opening possibilities for mimicking biological structures in a way that has been unprecedented in human history. The primary innovation proposed here is the development of a tool that generates bio-inspired, parametrically optimized cellular materials for integration into the design of Additively Manufactured ...

    STTR Phase I 2018 National Aeronautics and Space Administration
  8. Discrete Time State-Space Aeroservoelastic Modeling using FUN3D

    SBC: Zona Technology, Inc            Topic: A1

    CFD-based reduced order modeling (ROM) has been an active research area, as they can be used directly with common linear flutter analysis tools. Among them, linearized reduced-order modeling approaches rely on linearization of the nonlinear unsteady aerodynamic flow equations, assuming that the amplitude of the unsteady motion is limited to small perturbations about the nonlinear steady-state flow ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  9. Tunable Single Frequency UV Laser

    SBC: AdValue Photonics Inc            Topic: S1

    Compact and rugged single-frequency pulsed UV lasers are needed for measurement of ozone and the hydroxyl radicals (OH). The determination of the concentration of OH in the atmosphere is central to the understanding of atmospheric photochemistry. The goal for this SBIR Phase program is to demonstrate and build a highly robust high-power fast-tuning single frequency pulsed UV laser near 308nm for O ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  10. Wafer Level Hybrid Interconnect Aligned (Cu/Oxide) Bonding for 3D Integration of Heterogenous (Si/GaAs) Submillimeter-Wave Arrays

    SBC: Cactus Materials Llc            Topic: S1

    The objective of this work is to develop millimeter wave arrays with ultra-high accuracy alignment (<300nm) using hybrid aligned bonding. Currently, most submillimeter-wave array systems utilize a single pixel both for space as well as ground applications. While these approaches are workable for the near-term, they will become unsustainable as pixel count is increased. In addition, the shear ma ...

    SBIR Phase I 2018 National Aeronautics and Space Administration

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