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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. High throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity

    SBC: Celldom, Inc.            Topic: 300

    ABSTRACT The overall objective of this SBIR Phase I proposal is to develop a high throughput screening platform that can analyze the phenotypic heterogeneity of single cells exposed to small molecule growth inhibitors To achieve this objective we will conduct the following specific aims demonstrate a commercially viable approach for rapidly organizing andgt single cells into an arra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Fluorescent reporters for real time single cell Pol III transcription measurement

    SBC: Lucerna Inc.            Topic: 400

    SUMMARY RNA polymerase III Pol III is increasingly recognized as an important drug target and a rapidly developing area of academic research Pol III is responsible for generating RNAs that are critical for cell growth such as tRNAs certain rRNAs and various noncoding RNAs involved in processes such as mRNA splicing These RNAs are required for cell growth proliferation and differentiation ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Centralized assay datasets for modelling support of small drug discovery organizations

    SBC: COLLABORATIONS PHARMACEUTICALS, INC.            Topic: 400

    Summary The objective of Assay Central is to compile a comprehensive collection of datasets for structure activity data for a broad variety of disease targets and absorption distribution metabolism excretion and toxicology ADMET properties in a form that is immediately ready for model building and other forms of analysis using cheminformatics methods This is aided by the existence of many ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Plastic Parenteral Container with Superior Barrier Properties for Biologics

    SBC: TRIBOFILM RESEARCH INC            Topic: NHLBI

    PROJECT ABSTRACT Plastic offers several key advantages over Type borosilicate glass as a material for parenteral pharmaceutical containers e g vials and prefilled syringes Plastic is less prone to breakage and can be molded into more complex shapes with tighter dimensional tolerances than glass Additionally plastic is not susceptible to glass delaminati ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A phosphopeptide multiplex PRM mass spectroscopic biomarker assay for PAH

    SBC: Pulmokine, Inc.            Topic: NHLBI

    The purpose of this phase SBIR grant is to develop a quantitative phosphopeptide biomarker assay for pulmonary arterial hypertension PAH The commercial product will consist of a kit of stable isotopically labeled internal standards of a selected set of phosphopeptides either up or down regulated in PAH The set of stable isotopically labeled peptides will be used in a parallel reaction monito ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. FMRI Dynamic Phantom for Improved Detection of Resting State Brain Networks

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: NIDA

    Abstract Functional magnetic resonance imaging fMRI has rapidly become the dominant tool in human neuroscience research and is poised to become a transformative technology in the areas of psychiatric and neurological diagnostics In recent years large scale $ M $ B USD and long term year international investments e g NIDA Adolescent Brain Cognitive Development Study NIH Human ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases

    SBC: Eyedesis Biosciences, LLC            Topic: N

    PROJECT SUMMARY ABSTRACT Persistent disease activity PDA in spite of anti vascular endothelial growth factor VEGF therapy remains a significant clinical unmet need for patients with neovascular age related macular degeneration NVAMD The purpose of this STTR Phase I grant application is to develop novel therapies that will be effective for the treatment of PDA associated with NVAMD The cu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Web Software to develop an RDoC Compatible Adaptive Diagnostic Nosology the SID

    SBC: Health Outcomes Inc            Topic: 102

    n psychiatry clinical judgment has been the predominant method of diagnosis The `gold standard for clinical research is the Structured Clinical Interview for DSM SCID The SCID promotes reliability but its validity is questionable There is growing recognition that biomarkers can be used to identify more homogeneous patient populations but there is substantial phenotypic discordance f ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Personalized Neural Stem Cell Therapy for Cancer

    SBC: Falcon Therapeutics, Inc.            Topic: NCATS

    Project Summary Abstract Glioblastoma GBM is the most common primary brain tumor and one of the deadliest forms of cancer Standard surgery chemotherapy and radiation fail to eliminate the infiltrative invasive cancer cells Median survival remains only months Drugs that seek out the disseminated GBM cells behind the blood brain barrier will prevent the inevitable recurrence in patients ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High throughput CRISPR Cas cell line generation using the CellRaft Array platform

    SBC: Cell Microsystems, Inc.            Topic: NHGRI

    Project Summary Genome editing technologies such CRISPR Cas provide a rapid and targeted means of both knocking out gene expression and knocking in gene modifications However the current workflow required for CRISPR cell line generation relies on several technologies which reduce throughput efficiency and the overall viability of genome edited cells Cell Microsystems has developed a single ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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