Award Data

This Small Business Innovation Research (SBIR) Phase II project aims to develop a sub-micron x-ray tomography scanner capable of providing in-vivo and high resolution images of specimens from mice to bacteria. In this era of molecular medicine, where disease and developmental disorders are being re-defined by their peculiar molecular, genetic or cellular profiles, there exists a signif ...

The Phraselator, a handheld automatic translation device, currently uses a cardioic microphone as an input for automatic speech recognition (ASR). This microphone is highly vulnerable to performance degradation in typical noisy military environments and,thus, there is a need for an improved transducer for this application. We propose to develop a new directional microphone that is immune to extr ...

As the unmanned exploration of Mars and Venus becomes more of a focus area at NASA, inflatable, rigidizable wings will become an enabling technology. The successful development of this type of wing will also have significant military applications. The utility of unmanned aerial vehicles (UAVs) for the military has been dramatically demonstrated in the conflict in Afghanistan. Rigidization of infla ...

This Small Business Innovation Research (SBIR) Phase I project will develop a prepreg material that, while maintaining the advantages of a powder towpreg system, will eliminate the use of high price, finely ground powders. By generating fine particles in situ using aerosol formation from molten polymers two steps will be eliminated from the manufacturing process -- powder grinding and powder sin ...

DESCRIPTION (provided by applicant): The primary purpose of the proposed research is to develop, validate, implement, and norm a practical binaural assessment protocol that can be used clinically with bilateral cochlear implant patients. The protocol will be implemented in a computerized instrument to be developed in the course of the project. Binaural assessment of a cochlear implant patient will ...

DESCRIPTION (provided by applicant): The Apnea Risk Evaluation System (ARES) is an inexpensive, in-home method assessing for sleep-disordered breathing. ARES utilizes expert software to integrate analysis of nocturnal oxygen saturation, pulse rate, snoring sounds, head position/movement recordings acquired with a self-applied, portable single-site (forehead) device with analysis of responses to a ...

This Small Business Innovation Research (SBIR)Phase I project proposes to test the feasibility of extended delivery of ciprofloxacin from a novel lipid drug delivery vehicle : the vesosome. Ciprofloxacin is a valuable antibiotic whose therapeutic index would be enhanced with an extended release vehicle. Ciprofloxacin remains stably encapsulated in conventional unilamellar liposomes during storag ...

The ability to quickly estimate flight vehicle behavior in an operational environment is particularly important since engineers from a variety of disciplines require accurate predictions in order to plan flight test experiments, expand aircraft operating envelopes safely, and have access to diagnostic methods when problems arise. In order to minimize risks, and to maximize compatibility with prese ...

DESCRIPTION (provided by applicant): RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses, including HIV, hepatitis C, and West Nile virus, and thus represent attractive targets for therapeutics. Much of our previous work has centered on identifying and characterizing the components of key interactions and developing cell-b ...

DESCRIPTION (provided by applicant): The ultimate aim of the proposed research is to enable a substantial improvement in human kidney preservation prior to transplantation by extending the safe storage time and improving outcomes after any given period of storage. This proposal will build upon existing results indicating that a new renal preservation solution developed at 21st Century Medicine (R ...