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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Aging Resistant Ceramics for Total Hip Arthroplasty

    SBC: Amedica Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Zirconia bio-ceramics (e.g. Prozyr) have the highest toughness and strength compared to other bio-ceramics such as alumina (e.g. Biolox) or zirconia-toughened alumina (Biolox-Delta). However, as highlighted by the recent recall of St. Gobain zirconia heads, a critical need remains to develop bio-ceramics with both significantly reduced wear characteristics and ...

    SBIR Phase I 2003 Department of Health and Human Services
  2. Ultraviolet Light Devices for Vitamin D

    SBC: APOLLO LIGHT SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Vitamin D deficiency is now recognized as a significant health problem for middle-aged and older adults. Vitamin D deficiency exacerbates osteoporosis and causes the bone disease, osteomalacia. Vitamin D deficiency increases risk of skeletal fractures. It is well known that the ultraviolet B portion of the solar spectrum is responsible for the cutaneous product ...

    STTR Phase I 2003 Department of Health and Human Services
  3. N/A

    SBC: COGNITECH CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 2003 Department of Health and Human Services
  4. N/A

    SBC: COGNITECH CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 2003 Department of Health and Human Services
  5. Remote Telemetry for Neural Recording and Stimulation

    SBC: CYBERKINETICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this program is to create miniature, low-power neural signal recording and stimulation systems that can be controlled by short range (

    SBIR Phase I 2003 Department of Health and Human Services
  6. Liposome Overlays For Protein-Ligand Selectivity

    SBC: ECHELON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Phosphoinositides (PIPnS) are integral signaling molecules for cellular communication. By recruiting specific proteins to the inner membrane, signal cascades are then initiated leading to downstream effects such as protein sorting, tumorigenesis, regulation of exo-and endocytosis, control of cell shape, cell migration and proliferation, and apoptosis. Discoveri ...

    SBIR Phase II 2003 Department of Health and Human Services
  7. Discovery of Antagonists of Phosphoinositide Signaling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Phosphoinositides are key lipid second messengers in many cellular signaling processes. In particular, the activity of phosphatidylinositol 3-kinase (PI 3-K), and the synthesis of its lipid products, is important in pathways mediating cell proliferation, survival, and motility. Alterations in PI 3-K mediated signaling are common to many cancers. Targeting PI ...

    SBIR Phase I 2003 Department of Health and Human Services
  8. Screen for Isoprenoid Production in M. tuberculosis

    SBC: ECHELON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in all living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in many bacteria, these compounds are synthesized by an alternative, MVA-independent route whose first ...

    SBIR Phase I 2003 Department of Health and Human Services
  9. Fluorogenic Assays for Phospholipid Detection

    SBC: ECHELON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Phospholipids (PL) including phosphoinositides (PIPn) are crucial structural and signaling molecules for proper inter- and intra-cellular communication in an organism. The disruption of lipid homeostasis is associated with numerous human pathologies. High levels of LPA, LPC, PI (3,4,5) P3, PI (3) P and PI (4,5) P2 are linked to specific pathologies such as c ...

    SBIR Phase I 2003 Department of Health and Human Services
  10. Hybrid Phospholipid-Phosphoinositides

    SBC: ECHELON BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Phosphoinositide recognition by binding proteins and lipid-metabolizing enzymes involves specific interactions with the head group and diacylglycerol backbone, which vary significantly from protein to protein. When a fluorescent probe is introduced into the inositol head group, binding and metabolism are severely attenuated or abrogated entirely. When a fluores ...

    SBIR Phase I 2003 Department of Health and Human Services

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