List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Rapid Point-of-Care Salivary Diagnostic for Periodontal Health

    SBC: INNOVATIVE DIAGNOSTICS, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): The dental profession has searched for many years for additional real time chair-side measures to provide objective measures to aid in the monitoring of periodontal health and early diagnosis of disease. Research efforts have produced solid evidence that constituents present in saliva can provide important complimentary diagnostic information, and have the po ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Cerberus-LNR: A Tethered Lightfield 3D Endoscope for Advanced Minimally Invasive

    SBC: XIGEN, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The primary objective of this SBIR is to develop and pre-clinically evaluate a novel lightfield 3D endoscope, dubbed Cerberus-LNR, specially designed for laparoendoscopic single-site surgery (LESS), natural orifice translumenal endoscopic surgery (NOTES), and robotic LESS (R-LESS) (hereafter LNR) procedures. The miniature Cerberus-LNR lightfield 3D endoscope co ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Novel reporter cell lines for neurotoxicant assays

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): While it has been demonstrated that gene mutations are associated with an increasing number of neurodegenerative syndromes, environmental neurotoxicants remain a key factor in the etiology of many such diseases. For example, exposure to pesticides such as maneb and paraquat increase the risk of developing Parkinson's disease. Unfortunately, there is no opt ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Nanobind FFPE DNA/RNA Extraction

    SBC: Circulomics Inc.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Nanobind FFPE DNA/RNA Extraction Despite the growing need for and the demonstrated potential advantages of molecular biomarkers, it has proven difficult to routinely employ them in the diagnosis and management of patients. One reason for this failure has been the logistical challenges of obtaining, rapidly processing, storin, and transporting quick-frozen tissu ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Development of a non-destructive molecular extraction platform for quantitative p

    SBC: BIO-QUICK CORPORATION            Topic: NIEHS

    DESCRIPTION (provided by applicant): In this study, we propose a Non-Destructive Molecular Extraction (NDME) platform to perform quantitative proteomics analysis of FFPE specimens with SILAC cell dot controls. The NDME technique can directly extract proteins from a single fixed tissue section without destroying tissue morphology. The tissue section remaining after NDME will be used for histopathol ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Quantitative Real-Time DNA Repair Analysis Tools

    SBC: TREVIGEN, INC.            Topic: NIEHS

    Project Summary / Abstract DNA repair pathways maintain the integrity of the genome and thereby help prevent the onset of cancer, disease and aging phenotypes. Further, many cancer treatments function by inducing genomic DNA damage. As such, the critical requirement for DNA repair proteins and pathways in response to radiation and genotoxic chemotherapeutics implicates DNA repair proteins as prime ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Sustained-Release of a Novel Neuroprotective Agent for Improved Glaucoma Therapy

    SBC: GRAYBUG, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): Glaucoma is a major cause of blindness, affecting over 70 million people worldwide. It is a neurodegenerative optic neuropathy in which vision loss results from the loss of retinal ganglion cells (RGC). Current therapies are all directed at lowering intraocular pressure (IOP), however, despite IOP lowering, RGC loss still continues in many patients. To improve ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Sustained Release of a Novel IOP Lowering Agent for the Treatment of Glaucoma

    SBC: GRAYBUG, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): Glaucoma is a major cause of blindness, affecting over 70 million people worldwide. The development of glaucoma is most often associated with elevated intraocular pressure (IOP) which is induced by the dysfunction of the trabecular meshwork (TM) leading to inhibition of aqueous humor outflow. In most patients, constant elevated IOP results in the loss of retina ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Novel Biodegradable Injectable Rod for Improved AMD Therapy

    SBC: GRAYBUG, LLC            Topic: NEI

    ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in older adults with the neovascular form of the disease (NVAMD) mainly responsible for severe vision loss. Current NVAMD treatments involve repeated intraocular injections of biologics that neutralize vascular endothelial growth factor (VEGF), an important NV stimulus. Aflibercept, approved in late 2011, provides an ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Controlled release of a multi-functional therapeutic for the treatment of AMD

    SBC: GRAYBUG, LLC            Topic: NEI

    DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is the leading cause of blindness in older adults. The neovascular form of the disease (NVAMD) is primarily responsible for severe vision loss. Current NVAMD treatments involve repeated intraocular injections of biologics that neutralize vascular endothelial growth factor (VEGF), an important neovascular (NV) stimulus. Afl ...

    SBIR Phase I 2014 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government