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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. THE GOAL OF THIS RESEARCH PROGRAM IS TO DEVELOP A SELF-ADMINISTERED INTRANASAL TLR4 AGONIST TO TREAT ALLERGIC RHINITIS. UNLIKEANTIGEN-SPECIFIC THERAPY

    SBC: INIMMUNE CORP            Topic: 91

    The goal of this project is to develop an intranasal TLR4 agonist to treat allergic rhinitis.  Such treatment has the potential to provide short-term symptom control as well as long-term disease remission via allergen dependent T and B cell memory responses.

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Low Loss, Highly Nonlinear Waveguides for Transparent Optical Quantum Networks

    SBC: ADVR, INC.            Topic: 06a

    Quantum optical networks being developed by the DOE require all optical signal processing to preserve the quantum state of generated and transmitted photons. This requirement necessitates the development of transparent optical components with functionalities to support a quantum network. Robust, fiber packaged lithium niobate waveguide technologies can fit these needs in a suitable, scalable manne ...

    SBIR Phase I 2020 Department of Energy
  3. Micro-Pulse DIAL for Atmospheric Water Vapor Profiling

    SBC: Bridger Photonics, Inc.            Topic: 25b

    Water vapor plays a key role in Earth’s climate and weather patterns. Accurate, high resolution measurements of the water vapor vertical profiles in a region have been found to significantly improve the numerical weather prediction models’ short-term forecasts, precipitation forecasts, as well as severe weather forecasts. However, current measurement techniques provide very coarse resolution i ...

    SBIR Phase II 2020 Department of Energy
  4. Single application thixotropic antibiotic delivery systems for otitis externa

    SBC: Promiliad Biopharma Incorporated            Topic: NIDCD

    PROJECT SUMMARY Outer ear infections (otitis externa or OE) affect an estimated 10% of people in their lifetime, with associated healthcare costs amounting to over $500 million annually. The pathology is mostly treatable in the general population with topical antibiotics regimes, and can be supplemented in severe cases with systemic counterparts. However, incorrect application or non-compliance wi ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  5. PRODUCTION OF SYNTHETIC ADJUVANT SYSTEM (SAS): A SYNERGISTIC COMBINATION OF SYNTHETIC ADJUVANT COMPONENTS

    SBC: INIMMUNE CORP            Topic: 82

    There are very few FDA approved adjuvants available, limiting the discovery and development of vaccines to combat new pathogens that threaten public health. Inimmune Corp has developed a fully synthetic TLR4 agonist, INI-2002, with superior potency and stability versus other licensed TLR4 adjuvants. Simultaneously, Adjuvance Technologies has developed TQL-1055, a semi-synthetic and less toxic form ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Single Photon Frequency Convertor with High Quantum Efficiency

    SBC: ADVR, INC.            Topic: 06a

    The overall goal of this SBIR is to increase the accessibility and range of emerging all-fiber quantum networks by significantly advancing the state-of-the-art in optical quantum networks using fully integrated, single-pass, quantum frequency conversion (QFC). Fiber-based quantum networks, to take advantage of low losses and the wide range of existing network components and infrastructure, are exp ...

    SBIR Phase I 2019 Department of Energy
  7. Micro-Pulse DIAL for Atmospheric Water Vapor Profiling

    SBC: Bridger Photonics, Inc.            Topic: 25b

    Water vapor plays a key role in Earth’s climate and weather patterns. Accurate, high resolution measurements of the water vapor vertical profiles in a region have been found to significantly improve the numerical weather prediction models’ short-term forecasts, precipitation forecasts, as well as severe weather forecasts. However, current measurement techniques provide very coarse resolution i ...

    SBIR Phase I 2019 Department of Energy
  8. Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

    SBC: DiaCarta, Inc.            Topic: NIAID

    This pilot study is aimed at judging the efficacy of the lead compound with a clinically relevant allergenThe relevant allergen chosen for this study is the house dust mite Dermatophagoides pteronyssinus allergenDer pLoToxTM Natural Der pfrom Indoor Biotechnologies with a low endotoxin contentEUgWe are selecting this allergen because our team has extensive prior experience with this allergen in mo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Multifunctional Cold Chain Container for Unmanned Aerial Vehicle Transport

    SBC: RESODYN CORPORATION            Topic: ODCDC

    Development of an agile device that can deliver supplies to and from remote locations during public health emergenciesIn the context of emergency public health responsedrones could be extremely useful for transporting necessary supplies to remote or inaccessible locationsSupplies might include dry goodsbut would certainly include clinical specimensreagent kitsvaccines and other perishable goodsThe ...

    SBIR Phase I 2019 Department of Health and Human ServicesCenters for Disease Control and Prevention
  10. Acoustic Scaffold Bioreactor

    SBC: RESODYN CORPORATION            Topic: NHLBI

    This Small Business Innovation Research Phase II project will develop a commercially-viable device that uses micro-scale acoustic streaming (low frequency sound energy) to deliver mixing to the interior of three-dimensional (3D) scaffolds used for stem cell cultivation applications. The enabling advantage of low frequency sound energy is the ability to generate micro-scale mixing in and around sca ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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