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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. RIGID SUPPORTS FOR SOLID-PHASE PEPTIDE SYNTHESIS

    SBC: Biosearch Technologies, Inc            Topic: N/A

    PRELIMINARY RESEARCH PERFORMED AT BIOSEARCH, INC. HAS CONFIRMED THAT MODIFIED INORGANIC MATERIALS MAY HAVE SUPERIOR PHYSICAL AND CHEMICAL PROPERTIES FOR ATTACHMENT AND ASSEMBLY OF PEPTIDE CHAINS DURING SOLID-PHASE PEPTIDE SYNTHESIS. THESE SUPPORTS ARE BELIEVED TO PROVIDE A MORE MORE FAVORABLE ENVIRONMENT FOR THE CHEMICAL REACTIONS INVOLVED, AND THEIR RIGIDITY IS EXPECTED TO MINIMIZE PEPTIDE AGGREG ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. THE DITHIASUCCINOYL METHODOLOGY FOR PEPTIDE SYNTHESIS

    SBC: Biosearch Technologies, Inc            Topic: N/A

    AT PRESENT, PROGRESS IN PEPTIDE SYNTHESIS IS LIMITED BY THE RIGOROUS PURIFICATION AND CHARACTERIZATION PROCESSES THAT ARE NECESSARY IN BOTH OF THE TWO CURRENTLY ACCEPTED PEPTIDE SYNTHESIS METHODS. BIOTECHNOLOGY, AS WELL AS BIOCHEMICAL AND PHARMACEUTICAL RESEARCH, WILL BENEFIT FROM THE INTRODUCTION OF A NEW METHOD OF PEPTIDE SYNTHESIS THAT USES MILD REAGENTS. IT IS BELIEVED THAT INTRODUCTION OF A R ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. THERAPY FOR THALASSEMIA

    SBC: Biosym Technologies Inc.            Topic: N/A

    THE OVERALL OBJECTIVE OF THIS PROPOSED PROJECT IS TO EXTEND RECEPTOR-BASED DRUG DESIGN TO INCLUDE THE USE OF MODERN, STATE-OF-THE-ART SIMULATION OF THE STRUCTURE, ENERGETICS, AND DYNAMICS OF PROTEIN-PROTEIN AND PROTEIN-LIGAND INTERACTIONS. IN PARTICULAR, BIOSYM TECHNOLOGIES, INC. PROPOSES TO USE THESE TECHNIQUES TO MODEL AN ALPHA-HEMOGLOBIN TETRAMER AND TO USE INFORMATION OBTAINED FROM THESE STUDI ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. PORTABLE SYSTEM FOR CONTROL OF ANTICOAGULANT THERAPY

    SBC: Biotherm, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  5. PURIFICATION OF AN AUTOCRINE ANGIOGENESIS INHIBITOR

    SBC: California Biotechnology, Inc.            Topic: N/A

    A PROTEIN HAS BEEN IDENTIFIED FROM A CULTURED CELL LINE WHICH INHIBITS THE GROWTH OF CAPILLARY ENDOTHELIAL CELLS IN VITRO. THIS PROTEIN WILL BE PURIFIED FROM CONDITIONED GROWTH MEDIUM AND USED IN IN VITRO AND IN VIVO MODEL SYSTEMSTO TEST ITS ABILITY TO INHIBIT THE FORMATION OF NEW CAPILLARIES. THIS IS THE FIRST STEP TOWARD DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF SOLID TUMORS, VA ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. EXPRESSION VECTORS FOR SECRETED HUMAN ESTROGEN RECEPTOR

    SBC: California Biotechnology, Inc.            Topic: N/A

    THE LONG-TERM GOAL OF THE RESEARCH IS TO OBTAIN A CHINESE HAMSTER OVARY CELL LINE CAPABLE OF PRODUCING HUMAN ESTROGEN RECEPTOR AS A SIGNIFICANT AMOUNT OF ITS SECRETED PROTEIN. PURIFIED RECEPTOR PROTEIN MAY THEN BE USED (1) TO OBTAIN X-RAY CRYSTALLOGRAPHIC DATA ON THE STRUCTURE OF THE RECEPTOR TO AID IN RATIONAL ANTI-ESTROGEN DRUG DESIGN, AND (2) TO ACT AS A RESEARCH REAGENT FOR THE DEVELOPMENT OF ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. FORMULATION OF RECOMBINANT HUMAN LUNG SURFACTANT

    SBC: California Biotechnology, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  8. ANGIOGENESIS WITH ANTAGONIST AND AGONIST ANALOGS OF BASIC FGF

    SBC: California Biotechnology, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  9. INFORMATION RESOURCE ACTIVITIES IN CHEMOPREVENTION LITERA- TURE

    SBC: Ccs Associates            Topic: N/A

    THE OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION THAT MAY BE APPLIED TO THE IDENTIFICATION OF CHEMOPREVENTIVE AGENTS AND TO OTHER RESEARCH AND DEVELOPMENT PROBLEMS IN CHEMOPREVENTIOTHE DEVELOPMENT OF CHEMOPREVENTIVE AGENTS IS A HIGH-PRIORITYRESEARCH EFFORT AT NCI, PARTICULARLY FOR AGENTS THAT ARE EF-FICACIOUS AND SAFE FOR USE IN PATIENTS A ...

    SBIR Phase II 1987 Department of Health and Human Services
  10. INSTRUMENT CHANNEL FIBEROPTIC SPECTROSCOPY FOR GASTROINTESTINAL ENDOSCOPY

    SBC: Center For Planning & Research            Topic: N/A

    THE OVERALL OBJECTIVE OF THE PROPOSED PROGRAM IS TO DEVELOP A SPECTROSCOPE SUITABLE FOR USE WITH GASTROINTESTINAL ENDOSCOPY. THE SPECTROSCOPE DESIGN WILL UTILIZE A HIGH-INTENSITY LIGHT SOURCE COUPLED TO ONE OF TWO OPTICALLY ISOLATED QUARTZ LIGHT GUIDES IN A SHEATHED FIBEROPTIC BUNDLE. THE INSTRUMENT CHANNEL OF ANY COMMERCIAL ENDOSCOPE WILL SERVE TO GUIDE THIS FIBEROPTIC BUNDLE TO THE AREA BEINGEVA ...

    SBIR Phase I 1987 Department of Health and Human Services

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