Award Data

DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNTs) are the most toxic substances known to humans, causing respiratory failure. Because of their lethality and ease of production, the Department of Defense (DoD) designates BoNTs as a categoryA bioterrorism agent. Developing effective, post-exposure antagonists to BoNT is among DoD's top priorities. Despite their lethality, BoNT ...

DESCRIPTION (provided by applicant): Common acoustic environments are often complex mixtures of sounds from multiple acoustic sources. Some of these sources contain critical information listeners need to comprehend; others are distractions that interfere with listeners6 comprehension. As the US population ages, a significant and growing segment have difficulty coping with such complex sound fi ...

The overall goal of this proposed program (through Phase III) is to develop a chip-scale assay that can detect, identify, and quantify the presence of Category A (or B) bioagents in water at the required sensitivity (e.g. 8000 B. anthracis spores or 50µg of ricin per liter water) within 10 minutes. During the Phase I program feasibility was demonstrated by successfully detecting the capture of l ...

To reach high luminosity in a collider, its beam must be focused into a small-size spot at the interaction point (IP). Achieving such a small focal spot size requires expanding the beam to a rather large size at the final focusing quadrupoles. This is space consuming and leads to large chromaticity and chromatic beam smear at the IP. Compensating these chromatic effects proved challenging because ...

Diffractive waveplates are optical components made of thin films of anisotropic materials by modulating their optical axis orientation in the plane of the waveplate. The family of diffractive waveplates wherein this modulation is axially symmetricÂ? vector vortex waveplates (VVWs) Â? impart a spiral phase modulation at a light beam propagated through the waveplate. As a result, the intensity of ...

Redox flow batteries (RFBs) have the potential for economical storage of electrical energy than other battery chemistries. They use high-cost ion exchange membranes as separators between anolyte and catholyte, which prevent broad market penetration. Proton exchange membranes (e.g., Nafion) are poorly selective, allowing undesired cross-diffusion of active species in solution electrolytes across t ...

DESCRIPTION (provided by applicant): Substance abuse treatment is often complicated by problems such as depression, family and interpersonal conflicts, and legal issues. When these issues are addressed with effective, evidence-based treatments (EBTs), outcomes improve. To improve the quality of addiction treatment, experts have called for the adoption of a continuing care management approach, invo ...

DESCRIPTION (provided by applicant): The goal of this Type 2 Competitive Renewal SBIR application to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct a phase I/II clinical trial to investigate the safety and earlyefficacy of a novel antimicrobial living human skin substitute for the treatment of a life-threatening complication of diabetes: chronic, nonhea ...

ABSTRACT: Imagery analysts must frequently identify targets in rapidly changing environments where mistakes can have tragic consequences. LADAR is an emerging sensor technology that provides a rich data source for human analysts in support of combat identification. However, the primary focus of prior research has been on developing LADAR as a technology without adequately considering how an ana ...

ABSTRACT: The insertion of WAAS into the Air Force GEOINT analyst's arsenal of resources represents an evolutionary advance in potential real-time and forensic analysis capabilities. With the broad coverage areas that WAAS provides, analysts will be able to monitor individuals, groups, and vehicles across space and time, allowing them to more accurately and effectively develop patterns of l ...