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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. 3D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection

    SBC: SINTX TECHNOLOGIES, INC.            Topic: 400

    PROJECT SUMMARY—When neck and back pain becomes intractable, spinal fusion is the gold-standard treatment. However, up to 12% of these fusions fail due to infection, resulting in substantial personal and financial costs. In most cases, these infections are associated with the hardware used to stabilize the fusion. Traditionally molded or machined polyether ether ketone (PEEK) cages are widely us ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. A novel, hand-held, exhaled breath condensate sampler for the clinical research market; applications for asthma, pulmonary injury and inflammation.

    SBC: SENSIT VENTURES, INC.            Topic: NIEHS

    ABSTRACTExhaled breath is one of the most non-invasive human effluents that can be captured and analyzed, and yet it has minimal presence as a common clinical endpoint measurement in any branch of modern medicine. There has been a persistent technology gap for both breath sampling and breath analysis, despite the many vulnerable patient populations and age groups that could be aided by its use. Ex ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. HBI-002 to Treat Diabetic Retinopathy

    SBC: Hillhurst Biopharmaceuticals, Inc.            Topic: NEI

    PROJECT SUMMARY Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus and the leading cause of blindness in working age adults and elderly, affecting approximately 4.2 million diabetes patients in the US, of which 655,000 have vision-threatening DR. There is an urgent need for the development of additional approaches to prevent and treat diabetic retinopathy, as the curren ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma

    SBC: Algen Biotechnologies Inc            Topic: 400

    AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma PROJECT SUMMARY Drug discovery is a laborious, time-consuming, and expensive undertaking for biopharma. Oncology is especially difficult with new drugs in clinical trials having just 3.4% probability of success. This application addresses significant challenges of traditional drug target discover ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Engineering a long-acting relaxin agonist to treat liver fibrosis

    SBC: ZEBRA BIOLOGICS INC            Topic: 300

    Project Summary/AbstractRelaxin is a heterodimeric 53 amino acid peptide hormone that induces cardiovascular compliance and reproductive tissue remodeling during pregnancy and parturition. In addition to reproductive organs, the relaxin receptor, RXFP1, is also expressed in the liver, heart, lung, kidney, bone and skin. This broad tissue localization has led to the recognition that relaxin is a pl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Enhanced pancreatic islet cell engraftment by treatment with serpin B1

    SBC: SERPLUS TECHNOLOGY LLC            Topic: 200

    PROJECT SUMMARY The number of people with diabetes worldwide is predicted to increase from 415 million in 2015 to 642 million in 2040. The health care costs of treating diabetes accounts for 12% of the global health expenditure of which Type 1 diabetes mellitus (T1DM) constitutes 10-15% of the disease burden (IDF World Atlas 2015). T1DM is an autoimmune disease triggered by genetic and/or environm ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Multi-path DCS as a novel non-invasive treatment for amyotrophic lateral sclerosis

    SBC: PATHMAKER MOBILITY CORP.            Topic: 109

    PROJECT SUMMARY / ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the spinal cord and brain. ALS causes muscle weakness and paralysis and eventually death. According to the ALS Association, every 90 minutes there is a new diagnosis of ALS, as well as an associated death. Nearly 5,000 people are diagnosed with ALS each year and a ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Multi-Modal Fingertip Sensors for Prosthetic Hand Control and Feedback

    SBC: POINT DESIGNS, LLC            Topic: NIBIB

    Multi-Modal Fingertip Sensors for Prosthetic HandControl and FeedbackPROJECT SUMMARY / ABSTRACT The goal of the proposed project is to develop a robust, multi-modal prosthetic fingertip sensor – the Point Touch – which 1) has a patented multi-modal sensing capability including measurement of proximity, contact, and force and 2) can augment myoelectric control methods using semi-autonomous cont ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Diamond NMR spectrometer for microfluidic metabolite profiling

    SBC: ODMR Technologies, Inc            Topic: 400

    Project Summary. Nuclear magnetic resonance (NMR) is among the most powerful analytical techniques ever invented, as recognized by 6 Nobel Prizes for methods development alone. Nonetheless, NMR is notoriously plagued by poor sensitivity. State-of-the-art NMR spectrometers feature detection thresholds of ~1 nanomole for µL sample volumes (~100 nanograms). This places NMR sensitivity many orders of ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. High-throughput Single Cell Co-assay of Histone Modifications and Transcriptome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 400

    AbstractEpigenome analysis can help dissect the transcriptional regulatory sequences that control spatiotemporal patterns of gene expression during anima development and disease pathogenesis, but a major challenge to epigenome analysis is the heterogeneity of primary tissues. Conventional epigenome assays that take bulk tissues as input only produce population average signals. To address this majo ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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