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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201321 - 201330 of 207712 results
  1. Submillimeter Technology for Molecular Biomarkers

    SBC: LYNNTECH INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate objective of this research project will be the development and commercialization of a low cost, reliable and widely available point-of-care testing device for screening, diagnosis and management of disease in human patients. The proposed technique, submillimeter photoacoustic spectrometry of human breath, will initially be used to identify and q ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. A BioPhysical Approach to Resuscitation Fluids

    SBC: BIOPHYZICA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Circulatory, hypoxemic or traumatic arrest claims an estimated 350,000 lives per year in the United States accounting for almost 15% of all deaths. Circulatory, hypoxemic, or traumatic arrests result in whole-body ischemia, most significantly global cerebral ischemia. Brain cells die when they no longer receive oxygen and nutrients from the blood. Because cereb ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  3. 12-Lipoxygenase as a Target for Radiosensitization

    SBC: Biomide Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The arachidonic acid (AA) lipoxygenase pathway plays an important role in tumor progression through regulating cell survival, proliferation, and angiogenesis. Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of male death in the United States. During PCa progression, it is found that the expression of 12-lipoxygenase ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Radiosensitization by modulating inhibitors of apoptosis

    SBC: Ascenta Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Radioresistance markedly impairs the efficacy of tumor radiotherapy and involves anti-apoptotic signal transduction pathways that prevent radiation-induced cell death. The inhibitors of apoptosis proteins (IAP) are important intrinsic cellular inhibitors of apoptosis, highly expressed in prostate and lung cancer cells, and play an important role in resistance ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Prevention of cardiac cell death by Mst1 inhibitor

    SBC: VASADE BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Growing lines of evidence suggest that cardiac myocyte death, including apoptosis, is intimately involved in the pathogenesis of heart failure. Thus, an important therapeutic objective in reducing morbidity and mortality in patients with heart diseases is to prevent the cardiac myocyte loss, including apoptosis. We have recently identified that mammalian steril ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  6. CI Therapy and Novel Virtual Environments

    SBC: Metagenesis, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase I trial is to determine the rehabilitative effects gained through the use of a novel computer generated virtual scenario (VS), alone and with a protocol of constraint-induced therapy (CIT), for stroke rehabilitation. Efficacious results of a therapeutic protocol of VS and/or VS enhanced CIT (VS-CIT) could positively impact the lives of st ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. New anti-complement therapy to reduce reperfusion injury

    SBC: ENDOPROTECH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this proposal is to provide proof-of-concept that a novel therapy that prevents complement activation could be effective in reducing ischemia reperfusion injury (IRI) in transplanted organs. Complement activation after IRI in transplanted organs is a well-known phenomenon that may be responsible for delayed graft function and the hastening of ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Quantitative RT-PCR: Prediction Lymphoma Transformation

    SBC: IDAHO TECHNOLOGY            Topic: N/A

    DESCRIPTION (provided by applicant): Completion of the human genome and the advent of expression profiling have permitted comprehensive characterization of the transcriptional signatures of different disease states. Quantitative fluorescent real-time polymerase chain reaction-based methods have emerged as a powerful tool in molecular diagnostics as they combine extraordinary dynamic range of quant ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  9. Wavefront-based Deconvolution for Hi-resolution Imaging

    SBC: KESTREL CORP            Topic: N/A

    Retinal images remain an important diagnostic tool in ophthalmology. Today 35mm color images remain the "gold standard" by which new digital cameras are compared and judged. Over the past several years the number of pixels available to the digital camera has continued to increase to a point where the pixel footprint on the retina now closely matches the resolution that is allowed by the human eye. ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Improved NMR Sample Tubes

    SBC: Advanced Resonance Technologies, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Feasibility has been demonstrated for NMR tubes made from polymeric materials with novel geometries. These tubes offer greater sensitivity, easier sample recovery, greater flexibility and safety, reduced costs, improved response to magnetic fields, and new sampling possibilities. Sensitivity advantages may reduce the time required for many NMR acquisitions by n ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
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