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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201381 - 201390 of 205043 results
  1. Production of Chiral Aminoalcohols

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In Phase 1, the enzymatic reduction step for stereoselective synthesis of chiral vicinal aminoalcohols was established. Eight different ketoreductases were evaluated, including 5 ketoreductases that were cloned and expressed during this project, and the enzymes were characterized for substrate and stereochemical preferences. ...

    SBIR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  2. METHOD FOR NEONATAL SCREENING FOR HOMOCYSTINURIA

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  3. COUPLED ENZYME PROCESS FOR TRYPTAMINE SYNTHESIS

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    Neuroactive tryptamine derivatives can be prepared by a new coupled-enzyme process developed in Phase 1 by combining tryptophan-synthetic and -decarboxylating enzymes. This comprises the first reported single-pot aminoethylation process. The tryptamine products can thereby be conveniently produced from readily-available indole precursors. Expression systems which provide higher enzyme yields will ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  4. N/A

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. ACCURATE NONINVASIVE TEST OF STEATORRHEA IN INFANTS

    SBC: BIOCHEMANALYSIS CORPORATION            Topic: N/A

    DESCRIPTION (provided by the applicant): The long-term objectives of this proposed project are to develop a "Test Kit" for quantitative assessment of steatorrhea in infants without the need for control of dietary fat intake and quantitative collections of stools for several days as is the case with the current "Gold Standard," viz, the 72-hour fecal fat method. ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  6. Learning Drug Specifity in Protein Families by Docking

    SBC: BIOCOMPUTING GROUP INC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal is to provide a set of powerful docking-based rational drug discovery tools to take advantage of the increasingly rich amount of information on protein families sequence and structure emerging from genomics and structural genomics efforts. The tools will improve the reliability of current virtual screening methods by taking advantage of all availabl ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. Oral AmB for the treatment of fungal infection

    SBC: BIODELIVERY SCIENCES INTERNATIONAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goals of our research are to develop new formulations of therapeutically important drugs using cochleates as the delivery vehicle. Such formulations would have an improved route of delivery (oral rather than injectable to improve ease of administration and to reduce adverse effects of parenteral therapy), and lower tox ...

    SBIR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  8. N/A

    SBC: BIOELASTICS RESEARCH, LTD.            Topic: N/A

    N/A

    SBIR Phase I 2000 Department of Health and Human ServicesNational Institutes of Health
  9. N/A

    SBC: BIOELECTRIC CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 2000 Department of Health and Human ServicesNational Institutes of Health
  10. FLUORESCENCE SYSTEM FOR SENSING BIOSPECIFIC INTERACTIONS

    SBC: TIRF Technologies            Topic: N/A

    DESCRIPTION (provided by applicant): An innovative fluorescence system for sensing biomolecular interactions was developed in Phase I that is based on total internal reflection fluorescence (TIRF). The main advantages of this system are integrated microfluidics and a design that allows rapid replacement of TIRF sensor chip. The feasibility of building a highly sensitive and versatile TIRF biosenso ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
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