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DESCRIPTION (provided by applicant): Xcyte Therapies has developed a process ("Xcellerate") for the ex vivo activation and expansion of T cells using magnetic beads coated with antibodies to CD3 and CD28. Xcellerated T Cells from patients with CLL demonstrate an enhanced T cell repertoire, and the ability to induce the apoptosis of autologous tumor cells. Xcyte Therapies now plans to test this pro ...

This Small Business Innovation Research (SBIR) Phase II project focuses on the development of an enabling technology for computer- directed high-throughput screening of proteins with improved properties. Xencor's Protein Design Automation (PDA) predicts all the possible amino acid sequences that will fold into the three-dimensional structure of a protein. There should be molecules among those sequ ...

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As flip-chip bonding becomes the predominant standard in the electronics industry, the increased proximity between dice surfaces and packaging materials will require a significant reduction in the latter's alpha particle activity in order to avoid soft errors. Emission rates at or below 0.001 a/cm2/hr are desirable, which is well below the 0.0050 a/cm2/hr capability of today's best detectors. ...

65872 Efforts in nuclear nonproliferation, nuclear threat reduction, and counter terrorism require the detection of radionuclides at concentrations close to background levels. Enhanced isotope identification capabilities would increase the resolution for a number of telltale isotopes, enabling inspectors to verify nuclear events with greater accuracy. Also, security personnel would have a b ...

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Xidex and The University of Texas at Austin have successfully demonstrated the feasibility of developing a magnetic resonance force microscope for single proton imaging. Our Phase II work will demonstrate use of high-precision, high-sensitivitymeasurement of the magnetic force using (a) the high-Q mode of multiple torsional oscillators fabricated from single crystal silicon as the sensing element ...