Award Data

The current procedure for securing aircraft to a Navy flight deck is both manpower intensive, as measured in “blue-shirt billets”, and equipment intensive, requiring up to eighteen TD-1B chain tie downs per aircraft. As emerging Navy trends and tactics move towards reduced shipboard manpower and increased reliance on unmanned assets, Physical Sciences Inc. (PSI) introduces a pathway to new te ...

DESCRIPTION (provided by applicant): Photodynamic therapy (PDT) is a relatively new, rapidly developing, and promising modality for cancer treatment. PDT uses certain compounds known as photosensitizers (PS's) that are preferentially retained in malignant tumors. With visible light, the photosensitizers initiate a reaction that selectively kills the malignant cells to which they are attached. FDA ...

DESCRIPTION (provided by applicant): Photodynamic therapy (PDT) is a promising cancer treatment. PDT uses the affinity of photosensitizers such as hematoporphyrin derivative (HPD) and other compounds to be selectively retained in malignant tumors. When tum ors, pretreated with the photosensitizer (PS), are irradiated with visible light, a photochemical reaction occurs and tumor cells are destroyed ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), along with our RandD collaborators, Children's Mercy Hospital (CMH) and Cambridge Isotope Laboratories, Inc. (CIL), have performed Phase I investigations successfully demonstrating the feas ibility of a rapid, 13C labeled dextromethorphan (DM) breath test to assess CYP2D6 enzyme activity. Under the current Phase II application, PSI ...

DESCRIPTION (provided by applicant): Photodynamic therapy (PDT) is a relatively new, rapidly developing, and promising modality for cancer treatment. PDT uses certain compounds known as photosensitizers (PS's) that are preferentially retained in malignant tumors. With visible light, the photosensitizers initiate a reaction that selectively kills the malignant cells to which they are attached. FDA ...

DESCRIPTION (provided by applicant): (PSI), in collaboration with clinicians at University of Pittsburgh Medical Center (UPMC) Eye Center and a consultant from Massachusetts Institute of Technology (MIT), propose to develop a novel compact multimode adap tive optics (AO) retinal imaging system to study the characteristics of age-related macular degeneration (AMD). The system will integrate AO, s ...

DESCRIPTION (provided by applicant): Physical Sciences Inc., with our clinical partners in the Dept of Oral and Maxillofacial Surgery at the Massachusetts General Hospital, propose to develop a marking system for navigation during orthognathic surgery. The device can be used for both endoscopic and open procedures. It can be used to transfer treatment plans from computer-based 3D surgical plannin ...

DESCRIPTION (provided by applicant): Biodefense toxins such as ricin, botulinum neurotoxins, and Shiga toxin are a source of concern for terrorist attacks due to their high toxicity and the limited post-exposure treatment alternatives. Each of these protei n toxins exhibits an enzymatic activity that is the basis of its toxicity. Inhalation and ingestion are the primary routes of entry for protein ...

Physical Sciences Inc. (PSI) proposes to demonstrate a lithium ion battery electrolyte/separator system capable of high performance operation with improved safety at operating temperatures between -40 and 70oC. Continuously nano-porous structures, fabricated as thin battery electrode separator membranes will be used to sequester inexpensive liquid lithium ion battery electrolytes as a composite li ...

A novel methodology has been developed to predict both the steady and unsteady aerodynamic characteristics of complex fragment shapes resulting from the impact of Missile Defense Agency (MDA) interceptors with target vehicles. The particularly innovative unsteady force coefficient model provides for the calculation of fluttering, tumbling, and chaotic tumbling of fragments utilizing a rotational ...