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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201401 - 201410 of 205043 results
  1. Fast Field Screening of PFAS in Non-Portable Waters..

    SBC: 2witech Solutions LLC            Topic: NIEHS

    Project Summary/Abstract: 2Witech Solutions LLC proposes a Phase I Small Business Innovation Research project to develop a portable electrochemical sensing device for quick field screening of trace PFAS in non-potable waters (groundwater, surface water, and wastewater) by combining its recent achievement in molecular- imprinting technology and electrochemical sensor development. The overall object ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Flu Vaccine Production Using a Novel Pandemic Response and Prevention Manufacturing Method

    SBC: SOLARIS VACCINES, INC.            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT The current global pandemic has highlighted the need to develop new methods for creating vaccines. Many approaches today face limitations with breadth and duration of protection; flexibility and adaptability for emerging strains; manufacturing speed and safety; and storage and distribution. SolaVAX™ inactivation technology offers an elegant solution for quickly generatin ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput Discovery of Antibodies against Understudied Membrane Proteins

    SBC: INTEGRAL MOLECULAR INC            Topic: 300

    ABSTRACT Of the 20,000 genes in the human genome, approximately 4,000 are considered “druggable” by pharmaceuticals. However, less than 10% of these druggable proteins are actually targeted by FDA-approved drugs. In 2014, the Illuminating the Druggable Genome (IDG) project was launched by the NIH in recognition that there is a potentially large number of druggable targets with high therapeutic ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Developing a PIV5-based human metapneumovirus (HMPV) vaccine

    SBC: CYANVAC LLC            Topic: NIAID

    ABSTRACT In this Phase I SBIR application, we propose to develop an intranasal, parainfluenza virus 5 (PIV5)-based human metapneumovirus (HMPV) vaccine. HMPV is one of the leading causes of acute respiratory infections (ARIs) in children, immunocompromised individuals, and the elderly. Illness ranges from asymptomatic infection to severe bronchiolitis and pneumonia, with 90-100% of children infect ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Fluorescence-Solid Phase Extraction (F-SPE) Platform for Rapid, On-site Detection of PFAS

    SBC: Espira, Inc.            Topic: NIEHS

    Project Summary Per-and polyfluoroalkyl substances (PFAS) have become an emerging class of water pollutants that cause serious environmental and health concerns. Due to their wide use in industry, military, and fire protection, PFAS have been spread and present in all kinds of water bodies. Among the over thousand PFAS ever manufactured and used, perfluorooctanesulfonic (PFOS) and perfluorooctanoi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Self-organizing synthetic human lungs on microchips to fight infection by RSV

    SBC: RUMI SCIENTIFIC, INC.            Topic: NIAID

    Project Summary RSV is a major global threat that accounts for a significant share of respiratory disease and mortality among patients at risk. Infection by highly pathogenic RSV results in acute lung injury, LRTI, and pneumonia-associated complications. As treatments for RSV are very limited in use and efficacy, the development of physiological models of this disease is key to develop therapeutic ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Structure-guided neutralizing antibodies developed using EpiVolve technology

    SBC: ABBRATECH INC.            Topic: NIAID

    Abstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even after neutralizing Abs isolated are from human sample, they still need further characterization using ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Immunomodulatory biomaterial to enhancing T-cell responses to triple negative breast cancer

    SBC: SYMPHONY BIOSCIENCES, INC.            Topic: NCI

    Project Summary Deaths from solid tumors vastly outnumber deaths from hematopoietic cancers. Yet progress in immunotherapies for solid tumors is well behind those for lymphoma. CAR-T cell therapies and engineered T cells have become revolutionary approaches for hematopoietic cancers, but their potential for solid tumors is yet to be realized. Significant challenges hinder the potential of immune t ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. FOYC+ImPACT US: A digital platform for critical sexual health risk reduction curriculum customization and hybrid/remote delivery of Focus on Youth to underserved Caribbean youth in the U.S.

    SBC: DFUSION INC.            Topic: NICHD

    ABSTRACT – FOYC+ImPACT U.S. While there is extensive epidemiological data on the high rates of HIV, STIs and unintended pregnancies among Black populations in the U.S., this monolithic racial category problematically subsumes the ethnic diversity of immigrant Black populations. Today one in ten Black people in the U.S. are immigrants, with the Caribbean being the largest origin source. Caribbean ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. A Vascularized Blood-Brain Barrier Model for In Vitro Testing of Drug and Immunotherapy Delivery

    SBC: ARACARI BIOSCIENCES, INC.            Topic: 105

    PROJECT SUMMARY The brain is a highly-specialized, finely-tuned organ that depends for its function on maintaining homeostasis within narrowly-defined limits. This is achieved in large part by the Blood-Brain Barrier (BBB), which tightly regulates what can and can’t get into the brain. Functionally, the BBB is the combined work of endothelial cells (EC), pericytes and astrocytes, the latter two ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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