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Recombinant rabbit monoclonal antibodies as affinity captures for peptides PUBLIC HEALTH RELEVANCE

DESCRIPTION (provided by applicant): Since substantial neuronal loss has already occurred by the time Alzheimer's Disease (AD) manifests clinically, considerable research has been directed towards developing biomarkers for the reliable diagnosis of mild ADand the prodromal stage of mild cognitive impairment. The best studied biomarkers, A1-42 peptide and tau/P-tau, can distinguish cohorts of ...

DESCRIPTION (provided by applicant): RNA editing and post-transcriptional modification is emerging as a key epigenetic mechanism for fine tuning genetic diversity and RNA function of particular importance in the brain. However, while some RNA editing processes have been relatively well described, other RNA modifications are poorly understood and many questions remain about the true significance of ...

Not Available

DESCRIPTION provided by applicant With prediabetes and diabetes reaching epidemic proportions there is an urgent need to identify more effective therapeutics Diabetes is characterized by elevated levels of the peptide hormone glucagon and inappropriate suppression of glucagon during an oral glucose tolerance test Glucagon plays a major role in up regulating glucose release from the liver d ...

DESCRIPTION provided by applicant The development of addiction involves the dopaminergic reward pathway and downstream negative changes that lead to craving and repeat self administration While it is clear this process involves changes in neuronal plasticity t the synapse junction the exact changes at the protein level leading to the development of dependence and negative responses associated ...

Location 10151 Pacific Mesa Blvd. SAN DIEGO, CA 92121 United States N43DA0900023 $200 000.00 2 008 N/A Department of Health and Human Services National Institutes of Health SBIR PHS2009-1 AVANTGEN INC Phase I N43DA0900023 1 ...

There is an increasing appreciation that dogs with naturally occurring cancers may be a better model system for evaluating cancer therapeutics than the traditional mouse model systems. However, use of dogs for evaluating the emerging class of immunotherapeutics for oncology is limited by the availability of suitable reagents to mentor the response of the canine immune system. The majority of reage ...

Dogs with naturally occurring cancers can serve as a better model system for evaluating novel cancer immuno-therapeutics than the traditional mouse model systems, and also provide a target patient group. However, use of canine cancer patients is currently limited by the availability of suitable reagents to monitor canine immune responses. The majority of commercially-available reagents for canine ...

To develop rapid, point of care diagnostics for Hepatitis C virus.