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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201411 - 201420 of 207712 results
  1. Light Engineering Module for Fast High-Resolution Whole-Cell Imaging

    SBC: DOUBLE HELIX OPTICS, INC.            Topic: NIBIB

    Summary This SBIR Phase II project is focused on the design refinement, development, and testing of a ground-breaking multidimensional multifunctional quantitative optical microscopy modular system suitable for live whole cell studies. The proposed Light Engineering modular system addresses the critical need for flexible imaging techniques to image live whole cells with low photodamage and phototo ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. High-resolution extended-depth phase-engineered objectives to accelerate spatial 'omics RandD through computational optics

    SBC: DOUBLE HELIX OPTICS, INC.            Topic: 400

    Summary This SBIR Phase I project is focused on the design, development, and testing of groundbreaking engineered point spread function (ePSF) objective lenses, and matched computational algorithms for spatial omics research and development, which will be suitable for fixed and live-cell applications and will enable breakthroughs in fast live-cell spatial omics RandD by increasing the depth of fie ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Aim protein-based anti-inflammatory therapeutic for the treatment of IBD

    SBC: KEYBIOME LLC            Topic: 300

    Inflammatory bowel disease (IBD), which is subdivided into ulcerative colitis (UC) and Crohn’s disease (CD), constitutes a prevalent and growing clinical health problem worldwide. These diseases are characterized by debilitating symptoms including diarrhea, abdominal pain, and fatigue, and increased risk of gastrointestinal cancers. In addition, IBD patients have perturbed intestinal microbiomes ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Brain-wide quantitative mapping of microglia activation

    SBC: Translucence Biosystems, Inc.            Topic: 101

    SUMMARY Recent technological developments such as tissue clearing and light sheet imaging have allowed for the threedimensional visualization of the entire brain at cellular resolutionTranslucence Biosystems has advanced this technology further by developing aa proprietary Mesoscale Imaging System that allows visualization of an entire mouse brain much faster than prior techniquesbmachine learning ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Rapid Evaluation of Neuronal Activity in the Intact Whole-Brain at Single Cell Resolution

    SBC: Translucence Biosystems, Inc.            Topic: 101

    Project Summary New imaging tools are needed for brain wide visualization of the neural activity underlying defined behaviorsLive imaging techniques such as fMRI and MEG measure activity across the brainbut these methods cannot resolve single cell activityMoreoverin vivo electrophysiology and calcium imaging can reach cellular resolutionbut only simultaneously survey a few brain regions at bestCap ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Rapid Evaluation of Neuronal Activity in the Intact Whole Brain at Single Cell Resolution

    SBC: Translucence Biosystems, Inc.            Topic: 103

    Project SummaryHere we seek to develop a “Neuronal Activity Quantitative Diagnostic” platform and reagent kits to disseminate accessible products for measuring recent neural activity across the entire mouse brain to the neuroscience community. Previously we have shown that the activity-dependent immediate-early gene protein products Npas4 and cFos can be clearly detected, imaged, and quantifie ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Clearbot: a system for fully automated, high-throughput tissue clearing and immunostaining

    SBC: Translucence Biosystems, Inc.            Topic: 101

    SUMMARY Tissue clearing is a powerful technique that renders large biological samples optically transparent and allows 3D visualization of wide-brain molecular anatomy. To help disseminate this technology, Translucence Biosystems developed a Mesoscale Imaging System™ and, using previous SBIR NIH support, an analytical software package for advanced analysis of brain samples, 3TKTM. While complete ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Dual-view endoscopic probe

    SBC: OMNISCIENT IMAGING INC            Topic: 102

    DESCRIPTION provided by applicant Colon cancer is a leading cause of cancer death in the United States and overseas Colonoscopy is the preferred screening method at an estimated annual cost of over $ billion in the US Unfortunately many lesions are missed because pre cancerous growths remain hidden from view behind folds and flexures of the colon Current methods of increasing the field of ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Dual View Endoscopy for Colonoscopy

    SBC: OMNISCIENT IMAGING INC            Topic: 102

    AbstractAn estimatedmillion colonoscopies are performed annually in the US at a cost of about $Bhowever current colonoscopes with forward vision fail to detectof precancerous polypsOverof the missed polyps are located on or behind numerous folds in the colon where they are hidden from the sight of a forward view colonoscopeIn this research proposalwe propose to complete our development of an imagi ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Sedationless Multi-View High-Resolution Endoscopy

    SBC: OMNISCIENT IMAGING INC            Topic: 102

    Abstract An upper endoscope is designed for the endoscopic evaluation of the esophagus, stomach and duodenum, however, of the six-million upper endoscopies performed annually in the US, about half are for the disorders of the esophagus alone, where it can be argued that a full endoscopy of these three organs is not necessary in many, particularly since the procedure requires sedation with its asso ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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