Award Data

DESCRIPTION (provided by applicant):This project is a collaboration between ZeptoMetrix Corporation and Roswell Park Cancer Institute. The objective is to develop sensitive, quantitative and facile assays for measuring DNA damage caused by reactive oxygen species (ROS). ROS have been implicated in aging, cancer and several neurological diseases. Seven ROS-induced DNA lesions will be assayed, namel ...

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"The Phase I effort has shown that, through the combination of existing COTS technology and some novel systems, it is fully feasible to produce a tow behind vehicle capable of maintaining a set height above the ocean for the purposes of atmospheric fluxmeasurement. The Phase I design indicates that the system will be capable of meeting all the project requirements in a timely and cost effective ma ...

60293 Accelerator cells for the Next Linear Collider come in families of 200 different, but similar looking parts with tolerances varying from.5 to 50 microns. A total of 2,000,000 cells or 10,000 of each type need to be manufactured. Speed and repeatability associated with automated part handling is essential, and the automated robotic systems must be capable of comparable accuracy and ...

In May 1999, a Licensing Agreement between Zonagen, Inc. and the NICHD was finalized to develop new 19-substituted-norprogestins. If the new antiprogestins behave as tissue-specific modulators in the manner of selective estrogen response modulators (SERMs), they may be recognized as an analogous class of drugs, i.e., as SPRMs. Such SPRMs discovered by NICHD and realized as drugs through this SBIR, ...

The major goal of Phase I is to finish development of the CoagCare(TM) System, an Internet-enabled system for the automated management of oral anticoagulation therapy with warfarin. ZyCare, Inc. is developing detailed specifications for the system and is currently coding the software for the system. One U.S. patent has already been awarded for the CoagCare(TM) System and another is pending. Coa ...

Lower respiratory tract infections such as bronchiolitis and pneumonia in pediatrics and some adults are caused by respiratory syncytial virus. The therapies include the controversial ribavirin for treatment or humanized RSV monoclonal antibodies (Synagis) for prevention. The cost per season for Synagis prophylaxis is about US$ 5,000. In the absence of an effective vaccine, RSV remains a serious h ...

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APPLICANT'S DESCRIPTION: DNA fingerprinting, or profiling, is widely used for paternity cases and criminal investigations (forensics). Current methodologies are cumbersome, expensive and often fail to produce interpretable results. A minor groove binder (MGB) has been developed that greatly enhances the ability of oligonucleotide probes to discriminate single nucleotide polymorphisms (SNPs) in the ...