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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201421 - 201430 of 207728 results
  1. Improved methodologies to measure novel alcohol biomarkers in whole blood

    SBC: PHOENIX BIOSYSTEM, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Phosphatidylethanol (PEth) is a phospholipid formed only in the presence of ethanol via the action of phospholipase D. It has been measured in whole blood and proposed as a marker of ethanol abuse due to its high specificity and low degradation rate. The mean half-life of PEth in blood from alcoholics was found to be 4 days, and PEth was still measurable after ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Web-Based Training for EAP Alcohol Screening, Brief Intervention, and Referral

    SBC: Oregon Center For Applied Science, Inc            Topic: NIAAA

    DESCRIPTION (provided by applicant): Excessive alcohol consumption is a public health concern that causes approximately 85,000 deaths each year and costs the U.S. economy 185 billion annually. Because the large majority (79%) of adults with alcohol disorders are employed and Employee Assistance Programs (EAPs) are resources in 75% of U.S. businesses, EAPs are uniquely positioned to address this ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. Ultrananocrystalline Diamond Microarray Biosensor for Neurochemical Detection

    SBC: Advanced Diamond TechNologies, Inc.            Topic: NIAAA

    DESCRIPTION (provided by applicant): There is an acute need for the development of a new class of microarray biosensors that are sufficiently versatile, selective, sensitive and reliable to allow investigation of the time-dependent neurochemical events ofethanol administration in multiple regions of the brain. Currently, the preferred method for monitoring neurotransmitters in vivo real time is fa ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Mobile Tools for Improving Treatment of High Risk Alcohol Use in Primary Care

    SBC: TALARIA, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Primary Care Providers (PCPs) have the opportunity to identify and intervene with alcohol abusers and risky users at an early stage, preventing many negative health and societal consequences. Screening and brief intervention (SBI) for substance use problems is an effective treatment for high risk alcohol use as delivered in primary care settings. Unfortunately, ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Device for Delivery of Rolipram to Liver for Treatment of Alcoholic Liver Disease

    SBC: ENDOPROTECH, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Alcoholic Liver Disease (ALD) remains a leading cause of death from liver disease in the U.S., and there is still no FDA-approved therapy. Abnormal cytokine metabolism is a major feature of ALD. Elevated serum concentrations of tumor necrosis factor (TNF-) and TNF--inducible proinflammatory cytokines/chemokines, such as IL-8 and IL-18 have been reported in pati ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Automated Delineation, Parcellation and Analysis of the Cerebellum from MR Images

    SBC: Neurobehavioral Research, Inc.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Cerebellar involvement has been implicated in a large spectrum of disorders. Reduced cerebellar volumes have been reported in alcoholism, autism spectrum disorders, schizophrenia, mood disorders, and essential head tremors. As an example of the work demonstrating the more widespread role of the cerebellum in brain function, Sullivan and colleagues have demonstr ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  7. A suite of web apps for patients with alcohol and drug use problems in primary care

    SBC: BEHAVIOR THERAPY ASSOCIATES, LLP            Topic: NIAAA

    DESCRIPTION (provided by applicant): The annual healthcare costs of heavy drinking in the U.S. are estimated to be 24.6 billion (Bouchery et al., 2011). Effectively intervening with hazardous, risky, and problem drinkers would reduce both their morbidityand their healthcare costs. One way to address the needs of problem drinkers is by screening for and intervening with them in primary care. It is ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  8. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations

    SBC: CONDAX, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): As a normal consequence of aging, most men experience some form of erectile dysfunction (ED), which, in severe cases, causes impotence (the inability to sustain an erection sufficient to engage and complete vaginal intercourse). Conservative estimates place the incidence of all forms of ED in the general population at 30 million cases; the percentage in the ag ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Myeloperoxidase Inhibitors to Treat Alzheimer's Disease

    SBC: TORREY PINES PHARMACEUTICALS, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): The overall goal of the proposed research is to develop orally active inhibitors of myeloperoxidase MPO as a treatment forAlzheimer's disease. MPO is an abundant enzyme in leukocytes but its expression can be induced inastrocytes in Alzheimer's disease. This abnormal expression of MPO can lead to the oxidation of lipids and proteins leading to tissue ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  10. An Unobtrusive, Multi-individual Gait Monitor

    SBC: RESPONSE APPLICATIONS, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): We will develop an instrument to improve the healthcare of the most frail members of the elderly community. This population; elderly or recovering patients living at home or in an extended care facility is too frail toleave this environment and, as such, is subject to significantly reduced physical activity. Although numerous studies have confirmed that contin ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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