Award Data

Effective human-animal discrimination happens collectively at all levels of an UGS system. The ability to classify a target from ootsteps alone as human versus non-human given a single modality and sensor is challenging, thus a collaborative network effort increases the system Probability of Detection (Pd) and minimizes Probability of False Alarm (Pfa). IWT proposes leveraging inter-UGS communicat ...

DESCRIPTION (provided by applicant): The long term objective of this proposal is to develop a novel cell-based system for creating influenza-virus like particle (VLP) vaccines against epidemic and potentially pandemic influenza viruses. This strategy will generate in a rapid and safe manner VLP structures that morphologically and biochemically resemble wild type virus, but are devoid of influenza ...

DESCRIPTION (provided by applicant): Influenza virus-like particles (VLPs) have demonstrated in preclinical studies that they are highly immunogenic and efficacious in protecting against influenza infections. This emerging vaccine technology not only creates new vaccine candidates with alternative routes of administration (intranasal or intramuscular) but also implements a fast, flexible, and depe ...

DESCRIPTION (provided by applicant): We propose to develop a broadly neutralizing, possibly universal influenza vaccine based on virus-like particles (VLPs) displaying remodeled HA molecules which present otherwise cryptic epitopes. These remodeled HAs will be expressed in forms lacking the dominant hypervariable epitopes and instead display distinctly conserved subdominant antigenic sites known t ...

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a safe and efficacious virus-like particle (VLP) based-respiratory syncytial virus (RSV) vaccine to prevent the disease caused by this pathogen. The respiratory illnesses provokedby RSV in infants, children and the elderly are of global economical and public health impact. A recent worldwide estimate [5] indicates that ov ...

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Not Available Pyro-pulse compatible, non-explosive release devices will be developed for separation of satellites from launch vehicles for next generation of small spacecraft missions. Two design prototypes will be developed which utilize redundant shape memory actuators to provide both pyro-pulse compatibility, and multiple operation capability without refurbishment. Both designs will provide: L ...

In recent years there has been considerable interest in using natural plant fibers as reinforcements for plastics. The motivation includes cost, performance-enhancement, and weight-reduction. High- performance, bast fibers such as kenaf, and flax could potentially substitute glass or carbon fibers as reinforcements for plastics. The success of these short fibers as reinforcements in plastics depen ...

This Small Business Innovation Research (SBIR) Phase I project explores the feasibility of using a newly invented novel materials joining process based on electromagnetic theory as a reliable and economic method to weld tubular structures. The project will conduct research and engineering that will address the following critical technical hurdles for the commercial implementation and dissemination ...