Award Data

ABSTRACT Circadiandailyrhythms play a significant role in the efficacy and tolerability of cancer treatments in both rodents and humansDisruption of circadian rhythms disturbs sleep and has been shown to result in poorer survivorship rates in cancer patientsFurthermoreevidence suggests that timing treatments and interventions with circadian considerations can improve outcomesWhile knowledge of int ...

ABSTRACT Cancer patients often experience disruptions to their bodyandapos;s internal, circadian clock over the course of treatment, which contribute to worsened side-effects and quality of life. These side-effects include cancer- related fatigue (CRF), which affects millions of patients and can persist for months to years after the end of treatment. Despite the pervasiveness of CRF, the guideline ...

PROJECT SUMMARY Shift workers experience profound circadian disruption, which can have deleterious long term effects on their health and quality of life. Mood, fatigue, and performance can be improved in shift workers by moving the timing of their peak circadian drive to sleep outside the hours they are expected to work. This can be achieved with a targeted lighting intervention, as light is the p ...

PROJECT SUMMARY The broader impact of this Small Business Innovation Research Phase I project is to improve the clinical success and longevity of orthopedic prostheses for younger and active Americans to get relief from debilitating pain and to improve the quality of their life. The long-term survival of total hip replacements (THR) in young, active patients with higher demands remains a challenge ...

DESCRIPTION (provided by applicant): Many potent and specific peptides suffer problems of short or sub-optimal duration. A possible solution to such problems involves conjugation to macromolecules such as polyethylene glycol (PEG) that are slowly eliminated from the body, and thus prolongs the action of the attached peptide. For peptide therapeutics, it is usually essential that the unchanged drug ...

DESCRIPTION (provided by applicant): We are developing a platform technology that allows predictable, controlled release of drugs from macromolecule-drug conjugates. In one current format, PEG of sufficient size to have prolonged blood circulation times is attached to the drug by linkers designed to release the native drug at predictable and controlled rates. However, there are limitations to the ...

This Small Business Innovation Research Phase I project seeks to develop novel hydrogel drug-delivery systems. We have developed linkers for drug conjugation to circulating macromolecules that release the native drug by beta-eliminative cleavage at predictable rates with half-lives spanning hours to months, and do not require enzymes. However, a limitation of circulating carriers is that they are ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is an improvement in public health and quality of life through improved methods of medicinal therapy. The technology developed in this project is aimed at improving the effectiveness of existing therapeutic drugs while facilitating their use by patients in need of treatment, as well as enablin ...

We have developed a chemically controlled ultra long acting delivery system to support once weekly to once monthly administration of peptides In this system the peptide is covalently attached to a hydrogel microsphere depot by a cleavable eliminative linker upon subcutaneous injection the linker slowly cleaves and releases the drug If the same linker is used to attach two different peptide ...

A long acting parathyroid hormone PTH(1-34) for treatment of hypoparathyroidism Project Summary Hypoparathyroidism is a rare endocrine disorder characterized by low calcium (Ca2+) and high phosphate (Pi) levels in the setting of absent or low parathyroid hormone (PTH). Overall, an estimated 60,000 to 115,000 individuals in the United States have chronic hypoparathyroidism; most cases (~75%) result ...