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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201431 - 201440 of 207712 results
  1. Selective induction of endogenous IL10 for the treatment of uveitis

    SBC: ANVIL BIOSCIENCES LLC            Topic: NEI

    Project Summary Uveitis is an inflammatory disease of the eye that if inadequately treated can lead to vision impairment and blindness. Since the 1950's corticosteroids have been used as the main treatment option despite side effects from prolonged usagein severe and chronic uveitis. Research into uveitis has uncovered its underlying autoimmune mechanisms as facilitated by pathogenic lymphoc ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Peripheral administration of nonpeptide somatostatin agonists for ophthalmic dise

    SBC: Crinetics Pharmaceuticals, Inc.            Topic: NEI

    Project Summary With an increasing older population, including the generational aging of the baby boomers , age-related eye diseases are common and becoming more prevalent. Currently, it is estimated that 11 million Americans suffer from age-related macular degeneration (AMD) - a number that is expected to double in the next generation. The first world diabetes epidemic has also brought about a s ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Confocal and Autofluorescence Imaging of Macular Degeneration using a Low Cost Di

    SBC: AEON IMAGING LLC            Topic: NEI

    Project Summary / Abstract - PA-13-088 The overall goal of the proposed SBIR Phase I research is to build and begin initial evaluation of a low cost, portable retinal camera used to detect age-related macular degeneration and other retinal degenerations.Age-related macular degeneration remains the most common cause of permanent vision loss in the US and industrialized countries. The specialized i ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Wnt Modulator for Treatment of Age-related Macular Degeneration

    SBC: Charlesson, LLC            Topic: NEI

    PROJECT SUMMARY/ABSTRACT Age-related macular degeneration (AMD) is characterized by progressively decreased central vision and visual acuity and remains a leading cause of vision loss and blindness in aged Americans. Currently, the standard of care for AMD is intravitreal vascular endothelial growth factor (VEGF) inhibitors. Clinical studies have demonstrated that anti-VEGF drugs can slow or reve ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Novel Biodegradable Injectable Rod for Improved AMD Therapy

    SBC: Graybug Vision, Inc.            Topic: NEI

    ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in older adults with the neovascular form of the disease (NVAMD) mainly responsible for severe vision loss. Current NVAMD treatments involve repeated intraocular injections of biologics that neutralize vascular endothelial growth factor (VEGF), an important NV stimulus. Aflibercept, approved in late 2011, provides an ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Sterculic Acid Analogs to Inhibit Macular Degeneration

    SBC: L2 DIAGNOSTICS LLC            Topic: NEI

    ABSTRACT The long-term product goal of this project is a small molecule therapeutic for choroidal neovascularization (CNV, the hallmark of wet age-related macular degradation), an abnormal growth of blood vessels in the choroid layer of the eye that results in damage to the retina and consequent blindness. Our lead compound is the natural product sterculic acid, which has been shown to inhibit ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Designed Host Defense Peptides for the Treatment of Bacterial Keratitis

    SBC: Riptide Bioscience, Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): Bacterial keratitis, due to its potential to cause irreversible blindness, requires prompt intervention. In the United States there are approximately 30,000 patients annually, with contact lens wear being the prime riskfactor. Bacterial keratitis i presently treated with antibiotics however innovation in antimicrobial agents and treatment is needed due to the r ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of SAgA Therapy for clearance of NMO-IgG in patients with neuromyelit

    SBC: Orion BioScience Inc            Topic: NEI

    DESCRIPTION (provided by applicant): Orion BioScience Inc. has developed a Soluble Antigen Array (SAgA) therapeutic that displays multiple copies of aquaporin-4 epitope for targeted clearance of the auto reactive NMO-IgG antibody in patients with neuromyelitis optica (NMO). The product is intended to selectively clear NMO-IgG while limiting interaction with other non-NMO specific antibodies, the ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Retinal Prosthesis with Enhanced Thermal Imaging

    SBC: ADVANCED MEDICAL ELECTRONICS CORP            Topic: NEI

    DESCRIPTION (provided by applicant): We propose to develop and evaluate the utility of a thermal imaging system as an input modality to a retinal prosthetic. Retinal prostheses restore partial vision to people blinded by outer retinal degenerative diseasessuch as Retinitis Pigmentosa (RP) or Macular Degeneration. The Argus II Retinal Prosthesis System is intended to provide electrical stimulation ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Sign Finding and Reading SFAR on GPU Accelerated Mobile Devices

    SBC: LYNNTECH INC.            Topic: NEI

    DESCRIPTION (provided by applicant): The inability to access information on printed signs directly impacts the mobility independence of the over 1.2 million blind persons in the U.S. Many previously proposed technological solutions to this problem either required physical modifications to the environment (talking signs or the placement of coded markers) or required the user to carry around special ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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