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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201431 - 201440 of 207712 results
  1. High efficiency platform for rapid RNAi rat model development

    SBC: MIRIMUS, INC.            Topic: 100

    Abstract The cost of drug development has skyrocketed to an estimated $B for every FDA approved drug primarily due to failures from lack of efficacy or safetysuggesting that our current preclinical validation process has been insufficient in predicting therapeutic potential and toxicity in humansAnimal models are the gold standard for dissecting disease mechanisms and evaluating novel drug targets ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. CRISPR/Cas-mediated development of an RNAi rat model system

    SBC: MIRIMUS, INC.            Topic: 100

    Abstract The cost of drug development has skyrocketed to an estimated $2.6B for every FDA approved drug primarily due to failures from lack of efficacy or safety, suggesting that our current preclinical validation process has been insufficient in predicting therapeutic potential and toxicity in humans. Animal models are the gold standard for dissecting disease mechanisms and evaluating novel drug ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Preclinical Evaluation of a Novel ADAM10 Modulator to Treat ColorectalCancer

    SBC: MIRIMUS, INC.            Topic: NCI

    Abstract Colorectal cancer (CRC) is the third most diagnosed cancer in the USA and accounts for more than 600,000 deaths annually worldwide, primarily due to relapse with highly aggressive, chemo-resistant disease characterized by poorly differentiated cancer cells with stem cell-like properties. A common signature of these chemo-resistant tumors is dysregulation of Notch receptor signaling, as we ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. TB Diagnostics at the Point of Care

    SBC: ZETROZ SYSTEMS LLC            Topic: NIMHD

    DESCRIPTION (provided by applicant): Persistent pain is the number one reason that patients access the healthcare system according to the National institutes of Health. Pain seriously affects patients' quality of life and is associated with secondary morbidities such as depression, anxiety, and sleep disturbance. Medications are often the first-line treatment for pain relief, but they are not ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Hydrogel-based Long-duration ultrasound wound dressing to enhance cellular regeneration and rapid wound closure

    SBC: ZETROZ SYSTEMS LLC            Topic: A14AT016

    Therapeutic ultrasound is a common modality for pain management and rehabilitation therapy which has been clinically utilized for 60 years. Specifically designed ultrasonic devices for accelerated healing and wound site debridement are generally hand-operated bulky systems. As such, they are used on a case-by-case basis with irregular therapeutic treatment regimens dependent on patient access and ...

    STTR Phase I 2015 Department of DefenseArmy
  6. Self Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Underserved Populations

    SBC: ZETROZ SYSTEMS LLC            Topic: NIMHD

    DESCRIPTION provided by applicant Osteoarthritis OA is a degenerative disease of the joints which affects million Americans causing chronic pain limited mobility and overall reduction in the quality of life Americans with OA currently manage their symptoms through lifestyle changes weight loss exercise etc physiotherapy and medications to reduce pain and inflammation Although OA ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Innovative Wound Regeneration Support Approaches to Enable Rapid Treatment of Wounded Warfighters

    SBC: ZETROZ SYSTEMS LLC            Topic: A14AT016

    Ultrasound is a therapeutic modality which has been used clinically for 60 years, but has been limited in practice by the complexity of the technology. Recent research has allowed for the development of a portable, wearable, long duration, low intensity therapeutic ultrasound system. The system is powered by battery, and can be applied by a user to deliver up

    SBIR Phase II 2016 Department of DefenseDefense Health Agency
  8. Innovative Wound Regeneration Support Approaches to Enable Rapid Treatment of Wounded Warfighters

    SBC: ZETROZ SYSTEMS LLC            Topic: A14AT016

    Ultrasound is a therapeutic modality which has been used clinically for 60 years, but has been limited in practice by the complexity of the technology. Recent research has allowed for the development of a portable, wearable, long duration, low intensity therapeutic ultrasound system. The system is powered by battery, and can be applied by a user to deliver up

    STTR Phase II 2016 Department of DefenseDefense Health Agency
  9. Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis

    SBC: ZETROZ SYSTEMS LLC            Topic: NIA

    Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Daily and Localized NSAID Sonophoresis for Symptomatic Treatment of Knee Osteoarthritis

    SBC: ZETROZ SYSTEMS LLC            Topic: R

    Project Summary: Osteoarthritis (OA) is the most common type of arthritis, affecting over 30 million adults in the United States in 2015 and represents over 25% of medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of Health. Over 40% of individuals over 65 have symptomatic OA and reduced mobility due to the disease. OA pain is often mitig ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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