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We have developed a chemically controlled ultra long acting delivery system to support once weekly to once monthly administration of peptides In this system the peptide is covalently attached to a hydrogel microsphere depot by a cleavable eliminative linker upon subcutaneous injection the linker slowly cleaves and releases the drug If the same linker is used to attach two different peptide ...

A long acting parathyroid hormone PTH(1-34) for treatment of hypoparathyroidism Project Summary Hypoparathyroidism is a rare endocrine disorder characterized by low calcium (Ca2+) and high phosphate (Pi) levels in the setting of absent or low parathyroid hormone (PTH). Overall, an estimated 60,000 to 115,000 individuals in the United States have chronic hypoparathyroidism; most cases (~75%) result ...

The Nobel prize in chemistry recently awarded to Dubochet, Frank, and Henderson, for developing cryo-electron microscopy methods for high resolution structure determination in biomolecules is a testament to cryo-electron microscopy’s importance. While cryo-electron microscopy resolution, imaging cameras, and data analysis methods have developed considerably over the years, the preparation and ha ...

The Nobel prize in chemistry recently awarded to Dubochet, Frank, and Henderson, for developing cryo-electron microscopy methods for high resolution structure determination in biomolecules is a testament to cryo-electron microscopy’s importance. While cryo-electron microscopy resolution, imaging cameras, and data analysis methods have developed considerably over the years, the preparation and ha ...

Two-thirds of oral and oropharyngeal squamous cell carcinoma (OSCC) occur in low- and middle-income countries (LMICs), the 5-year survival rate is only 10-40. Enough is already known about the disease and its prevention for action to be taken. The poor survival rate in LMICs is mainly due to late diagnosis. Therefore, it is imperative to detect precursor and malignant lesions early and expeditious ...

Oral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancer worldwide, it is the most common cancer in some low- and middle- income countries (LMICs). The poor survival rate in LMICs and rural regions in developed countries is mainly due to late diagnosis and the resultant progression of disease to an advanced stage at diagnosis. Motivated by the successes i ...

The goal of this SBIR project is to develop and commercialize a fundamentally new type of all-reflective microscope (ARM) without any obscuration for full spectrum applications from ultraviolet (UV) to infrared (IR). In Phase I stage, Light Research Inc (LRI) will demonstrate ARM by designing, prototyping, and characterizing a high numerical aperture (NA) reflective objective and tubing lens. Curr ...

DESCRIPTION (provided by applicant): The broad, long-term objective of this Phase II grant proposal is to improve accuracy of breast cancer diagnosis. Specifically, this Phase II grant proposal is for clinical testing of a new technology that will prom

DESCRIPTION (provided by applicant) Phase I The long-term objective of this project is to improve the consistency and standardization of clinical cancer diagnostic testing of tissue biopsies. There are increasing numbers of cancer therapeutics that ar

DESCRIPTION (provided by applicant) Phase I The long-term objective of this project is to improve the consistency and standardization of clinical cancer diagnostic testing of tissue biopsies. There are increasing numbers of cancer therapeutics that are linked to immunohistochemical diagnostic tests. Patient therapy is directly affected by the quantitative results of such testing. The absence o ...