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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201441 - 201450 of 204455 results
  1. Commercializing CivaSheet for Pancreatic Cancer Patients

    SBC: CIVATECH ONCOLOGY INC            Topic: NCI

    CivaTech Oncology’s mission is to provide improved radiation therapy directly to diseased tissues while sparing healthy tissues. With NIH/NCI SBIR support, the Company has eliminated local recurrence of disease in pancreatic cancer patients – a huge success. Pancreatic cancer is predicted to soon become the most commonly diagnosed cancer in the US and there are no significant, impactful therap ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A small molecule integrin activator to enhance cord blood transplant

    SBC: 7 Hills Pharma LLC            Topic: NHLBI

    PROJECT SUMMARY This proposal is in response to the parent announcement for Phase II STTR (R42) grant applications. Hematopoietic stem cell transplantation has become a preferred treatment for hematological malignancies and certain genetic disorders. Umbilical cord blood has become an appealing alternative to bone marrow or peripheral blood as a source of hematopoietic stem cells for transplant. D ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Subcellular imaging of biochemical processes within human retina

    SBC: Polgenix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of age- and disease- related changes in the eye, long before pathological manifestations of retinal disea ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Exploiting synthetic lethality of hematopoietic lineage cells to develop novel ta

    SBC: Cellecta, Incorporated            Topic: NCI

    DESCRIPTION (provided by applicant): Targeted therapies have the ability to specifically interact with and block proliferation of cancer cells by interfering with targeted gene products required for the malignant phenotype. Unlike conventional cancer chemotherapies, targeted therapies do not harm normal cells of the body. This class of therapeutic has been met with considerable clinical success i ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Cross-Sortie Flight Route Optimization

    SBC: ON TIME SYSTEMS, INC            Topic: AF03094

    Both the USAF's Air Mobility Command (AMC) and commercial carriers must route multiple aircraft efficiently despite multiple, possibly conflicting requirements (minimize fuel burn, rendezvous on time, etc.). Phase I demonstrated the technical feasibilty of finding optimized routes for a collection of sorties using a combination of parallel distributed processing and advanced search technology. Th ...

    SBIR Phase II 2004 Department of DefenseAir Force
  6. IND FIH study and month tox for PTI a novel therapeutic for Alzheimer s disease

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    PTI is a novel compound with a novel target designed to treat and slow the progression of Alzheimer s disease AD PTI binds with femtomolar affinity to a particular site on filamin A FLNA a scaffolding protein we recently demonstrated is critical to beta amyloid s toxicity Beta amyloid A exerts its toxic effects by hijacking the nicotinic acetylcholine receptor nAChR ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of VLP vaccine for RSV

    SBC: SIGMOVIR BIOSYSTEMS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Respiratory syncytial virus RSV is a substantial threat to human health most severely affecting three large populations infants young children and the elderly Despite the significance of RSV disease in these different populations there are no vaccines available The goal of this Phase II STTR project is to continue preclinical testing of a novel RSV vac ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: 101

    Project SummaryRadiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing, with a substantial number of large and small pharmaceuticals companies developing products in this area and radionuclide producers making substantial investmen ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. ExoSOUND:An Acoustofluidic Device for Exosome Isolation

    SBC: Ascent Bio-Nano Technologies Inc            Topic: 400

    Project Summary Exosomes are extracellular vesiclesnmfound in nearly all biological fluidsincluding bloodurinesalivaand cerebrospinal fluidIn recent years they have emerged as a potentially powerful tool for biomedical researchbiomarker discoverydisease diagnosticsand health monitoringExosomes perform diverse cellular functions such as intercellular communicationantigen presentationand transfer of ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. System for Increasing Patient Access to Eye Exams for Diabetic Retinopathy

    SBC: AEON IMAGING LLC            Topic: NEI

    DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to implement and evaluate a low cost retinal camera, the Laser Scanning Digital Camera (LSDC), in a system for diabetic retinopathy (DR) screening. Untreated DR has reached epidemic levels in underserved populations worldwide. As the LSDC has already demonstrated its readiness for DR screening in preliminary stud ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
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