Award Data

In this proposal, Physical Sciences Inc. (PSI) outlines the development of a system for remediating ammonia (NH3) produced in large confined animal feeding operations (CAFOs). The animal agricultural industry is coming under increased scrutiny due to the large volume of pollutants, in particular ammonia, produced in its operations. PSI's proposed remediation system for NH3 utilizes an adsorbe ...

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Lucid, Inc., proposes to investigate the use of combined reflectance confocal microscopy- polarization sensitive optical coherence tomography (RCM-PSOCT) for in vivo diagnosis of skin cancers. Both RCM and OCT are powerful technologies with proven success in ...

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR RandD proposal is to develop a solvent vapor mass flow monitoring instrument that will enable pharmaceutical companies to develop and monitor drug production processes based on Quality by Design (QbD) principles, supporting the FDA QbD initiative. The production of pharmaceuticals, including drugs for cancer treatment, often requir ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. and its collaborators at Medical Modeling Inc. and the Brigham and Women's hospital propose to develop software for planning maxillofacial surgery. The software will complement the OsteoMark system under development at PSI and will be integrated with the current surgical planning process used by many surgeons. Current software for p ...

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA proposes to investigate the use of combined Raman microspectroscopy-Optical Coherence Tomography (OCT) imaging for in vivo diagnosis of tooth decay, cracks, and periodontal diseases. Both Raman and OCT are powerful technologies with proven success in human tissue diagnosis ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn), proposes to develop the 2nd generation of an advanced 3D freeze-drying microscopy (FDM) system to advance the understanding of freeze-drying and to enable the development of efficient commercial freeze drying processes. During the Phase I program PSI demonstrated the app ...

The development of biologic drugs for cancer treatment often requires formulations that must be lyophilized to produce stable drug products. The process of developing a drug formulation and freeze drying process begins with laboratory experiments followedby scale-up to pilot and production scale lyophilizers. A major challenge during early formulation and lyophilization process development is the ...

DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Massachusetts General Hospital proposes to investigate the use of a high sensitivity/specificity cancer targeting agent and of a novel fluorescence-guided microscopy(FGM) scheme for intraoperative assessment of surgical margins in breast cancer patients. The contrast agent will be used to label cancer cells a ...

DESCRIPTION (provided by applicant): The goal of the proposed SBIR program is to develop lyophilizer manufacturing hardware and processing procedures that enable the efficient freeze drying of pharmaceutical product formulations in prefilled syringes. Theuse of prefilled syringes 1) reduces dosing and medication errors, 2) reduces the risk of microbial contamination, 3) improves dosing accuracy, 4 ...

DESCRIPTION (provided by applicant): There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address this need, Physical Sciences Inc. (PSI), in collaboration with MGH Voice Center, will develop a clinically-viable imaging system that will integrate optical coherence tomography ( ...