Award Data

The goal of this project is to generate rabbit monoclonal antibodies to selected five biomarkers of immune cells in order to study immune response in guinea pigs.

Hepatitis C Virus (HCV) infection is a worldwide health concern, affecting about 3% of the world’s population. Over 2 million people in the United States have a current HCV infection, however, nearly half of them are not aware of their infection. HCV-related end stage liver disease is the leading reason for liver transplantation in the USA. Because symptoms are generally absent in individuals wi ...

Swine is a useful animal model for studying human health and diseases. Particularly, swine is currently preferred candidate species as the source animal for xenotransplantation. However, the usefulness of pig for biomedical research has been constrained by the lack of reagents targeting immune markers involved in tissue/organ rejection. The objectives of this proposal are to generate rabbit monocl ...

Syrian golden hamsters are valuable animal models for studying metabolic disease and human infectious diseases including SARS-CoV-2. However, the usefulness of the hamster as a small animal model for biomedical research has been constrained by the lack of immunological reagents. In this proposal, the Offeror proposes to develop affinity reagents for eight immune targets of Syrian golden hamsters t ...

ABSTRACT: Freedom Photonics is proposing to develop a high-power integrated advanced modulattion format reansmitter with high output power and operating in the 1450-1500nm window. This is achieved through the adaptation of our current Indium Phosphide integration platform from 1550nm to this wavelength range. To reach our goal, a combination of a tunable DBR laser, a high-speed advanced modulatio ...

This proposal seeks to build build a widely tunable laser (>20 nm tuning) with the phase noise performance sufficient for use with existing fiber optic interferometer hydrophone sensors on Virginia Class Submarines. In Phase I, we propose to conduct a feasibility study of modifying a widely tunable laser design to achieve low linewidth. Monolithic Photonic Integrated Circuit (PICs) technology has ...

We propose to develop a reflectometer, leveraging our existing tunable transceiver technology at the core, both as a standalone product and also as an added capability that can be incorporated into transceiver modules. The development of a full design for the tunable, high-power, low phase noise laser for stable optical sources for high performance atom sensing applications is ideal for the next g ...

ABSTRACT: We propose to develop a tunable, versatile high-efficiency, optical free-space link including the transmitter and receiver with an adaptive modulation capability. The development of adaptive modulation will be achieved through the study of contrasting approaches for adaptive modulation including data clock-rates and adaptive modulation formats. BENEFIT: This new adaptive modulation te ...

ABSTRACT: Next generation defense and commercial satellites will acquire and process data at significantly higher rates than current satellites. This will necessitate the development of high speed fiber optic communications infrastructure for intra-satellite communications, including the development of highly reliable space-qualified transceivers. This work is expected to provide a very small for ...

ABSTRACT: Currently, typical LIDAR (Laser RADAR) systems single-aperture is limited by the size and weight of the necessarily large optical aperture. During targeting the camera/imager is quickly extended and then retracted to minimize the time the LO of the aircraft is impacted. In a distributed aperture system, several receiver sub-apertures may be combined to form an effective single larger ap ...