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Clonogneic assays measure the ability of single cells to proliferate and form a colony This process approximates closely the regrowth and recurance of tumors after treatment with radiation or chemotherapy providing a ready assay to screen for drugs that block this process Yet clonogenic assays are laborintensive and too cumbersome for high throughout screening HTS of compound libraries Here ...

Clonogenic assays measure the ability of single cells to proliferate and form a colonyThis process approximates closely the regrowth and recurrence of tumors after treatment with radiation or chemotherapyproviding an assay to screen for drugs that block this processYetclonogenic assays are labor intensive and too cumbersome for high throughout screeningHTSof compound librariesHere we propose to de ...

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a STAT palm-sized blood counter for monitoring complete blood counts (CBC) during emergencies. Changes in blood counts can reflect acutely worsening medical conditions. For instance, a rapidly rising white blood cell count may occur during infections or leukemic blast crises. Hematocrit values may rapidly decline in traum ...

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a STAT palm-sized blood counter for monitoring complete blood counts (CBC) with 3-part differential during emergencies. Changes in blood counts can reflect acutely worsening medical conditions. For instance, a rapidly rising white blood cell count may occur during infections or a leukemic blast crises. Hematocrit values m ...

LiquidPiston, Inc. is developing a new engine technology that is uniquely positioned to provide a solution to the Army’s objectives for an improved compression ignition engine. LPI’s new High Efficiency Hybrid Cycle (HEHC) engine will have the following predicted characteristics: Compression Ratio: Variable, from 15:1 to 28:1 Power: 650HP Efficiency, at all power loads: >42%, potentially ...

This Phase I SBIR Program will demonstrate and help mature the use of mechanical alloyed, thermally stable nanocrystalline aluminum alloys produced by extrusion and roll Processing. These nano strengthened alloys are sensitive to manufacturing processes, but offer the potential for thermally stable nanocomposite aluminum alloys showing a 100% increase in strength over current aluminum alloys, whil ...

In this program Powdermet will combine controlled particle packing theory, particle interface control through particle coating and improve particle aeration by combining energetic gas formers within the obscurant compact. The end result of the program will be a device that outperforms current burster canisters with existing available obscurant materials and also can be applied to newly developed ...

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The proposed Phase I SBIR program will result in the development of an innovative, net shape processing technique which enables nanolevel control over composite compositions combined with independent rnacrolevel control over microstructures to achieve improved ceramic matrix composite materials The program will result in higher strength and modulus, lighter-weight, more environmentally resistant, ...

The replacement of Berylium, for toxicity reasons, is an issue facing Europe and the US. Berylium is a popular engineering material because of it light weight and high stiffness. The Phase II program being proposed is one capatlizing on the Phase I effortin achieving light weight materials with Moduli in excess of 26 million on high volume reinforced SiC with an Al matrix. Also in development is ...