You are here

Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201471 - 201480 of 204654 results
  1. An Efficient Fully 3-Dimensional Cell Migration Assay

    SBC: Platypus Technologies, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The goal of this SBIR project is to design and develop an efficient, physiologically relevant and cost-effective 96-well 3-D Cell Migration Assay that is compatible with mid-high throughput/high content assay platforms.Due to its importance in cancer and associated metastatic processes, cell migration is intensively studied and in vitro cell migration assays a ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Kidney Progenitor Cells in Regenerative Medicine

    SBC: PROBETEX INC            Topic: NIGMS

    Project Summary: We have shown that rat and mouse metanephric mesenchyme (MM) and ureteric bud (UB) cells undergo reciprocal induction to form differentiated tubular epithelium and undergo vasculogenesis forming capillary-like structures in 3-dimensional culture. Because these kidney progenitor cell lines retain differentiation potential, they have enormous potential in state-of-the art areas of r ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization and Lead Selection of Novel Antimycobacterial Agents

    SBC: CRESTONE, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The non-tuberculous mycobacteria (NTM) are a growing public health concern as the number of opportunistic infections increases. Although not a reportable disease, there is growing epidemiologic evidence to suggest thatNTM cause more infections today in the United States than Mycobacterium tuberculosis (Mtb) yet, unlike Mtb, there are few dedicated antimicrobia ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Recombinant antibodies for antibody arrays

    SBC: MESO SCALE DIAGNOSTICS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop a rapid, low cost and high-throughput method for generating recombinant engineered antibodies with improved properties for proteomic and immunoassay applications. Engineered antibody constructs such as recombinant Fab fragments and chimeric antibodies will be generated and expressed by directly modifying the antibody genes in antibody-pro ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Developing Novel Peptide Arrays for Epigenetic Research

    SBC: Epicypher, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): It has been increasingly appreciated that perturbations in epigenetic processes are associated with diverse human diseases such as cancer and immunodeficiency disorders. To date, more than 100 histone protein posttranslational modifications (PTMs) have been described. However, characterization of the enzymes that catalyze the modifications and the proteins that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. DNP-enhanced Tissue HRMAS MRS- Towards Measurements of Single-Cell Metabolomics

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The proposed research focuses on the development DNP-enhanced high-resolution magic-angle-spinning (HRMAS) magnetic resonance spectroscopy (MRS) to quantify cellular metabolities within intact prostate tissue. This willallow the study of micro-dissected pure pathological features, which is currently not possible due to the sensitivity limitations of the method ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Novel APCI source

    SBC: MASSTECH, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Significant increase in the efficiency and speed of atmospheric pressure chemical ionization (APCI) in tandem mass spectrometry (MS/MS) will have a profound impact on its applications to the entire analytical field of characterization of drugs, metabolites, lipids, steroids, etc. A broad applicability of APCI-based MS analysis makes it a unique analytical tool ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Deciphering the poly-ubiquitin code with isopeptide selective antibodies

    SBC: LIFESENSORS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Ubiquitin (Ub), a 76 amino acid protein, is implicated in protein degradation and a myriad of cell signaling pathways, including DNA damage response, protein trafficking, cell-cycle progression, inflammation, immune response and regulation of apoptosis. Ubiquitylation occurs through formation of an isopeptide bond between the C-terminus of Ub and the ?-amino gr ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Antibodies to O-GlcNAc modified histones for chromatin biology and epigenetic res

    SBC: GLYCOSCIENTIFIC, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): O-glycosylation of nuclear and cytoplasmic proteins by a single ?-N-acetyl-D-glucosamine moiety (O-GlcNAc) is a common post-translational modification that is highly dynamic and fluctuates in response to cellular stimuli. This type of glycosylation has been found on approximately a thousand human proteins to date, and is thought to be nearly as wide-spread and ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Bright and Fast Sensors for Radioluminescence Microscopy of Single Living Cells

    SBC: RADIATION MONITORING DEVICES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Radioluminescence microscopy is a newly developed method for imaging radionuclide uptake in live single cells. Current methods of radiotracer imaging are limited to measuring the average radiotracer uptake in large cellpopulations and, as a result, lack the ability to quantify cell-to-cell variations. With the new radio- luminescence microscopy technique, howe ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government