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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201481 - 201490 of 204843 results
  1. Development of a Porcine Model of Juvenile Neuronal Ceroid Lipofuscinosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is an autosomal recessive disorder caused by mutations in the CLN3 gene with a worldwide incidence of 1 in 12,500 live births. It is part ofa group of lysosomal storage disorders - the neuronal ceroid lipofuscinoses (NCLs) - that together constitute the most common neurodegenerative d ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. XT-101: A Potent IL-10 Based Therapy for Treating Multiple Sclerosis.

    SBC: XALUD THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Xalud Therapeutics proposes to evaluate the applicability of its novel and potent anti-inflammatory therapy, XT-101, for the treatment of motor impairment, gait disorders, and neuropathic pain in degenerative and inflammatory autoimmune rodent models of multiple sclerosis (MS). XT-101 is a non-viral form of gene therapy that causes the meningeal cells surround ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel Inhibi

    SBC: SITEONE THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Side effects associated with opioid analgesics, such as nausea, drowsiness, respiratory depression, and potential for addiction, are motivating the design and development of new therapies for acute, subacute and chronic pain. Voltage-gated Na+ ion channels are integral membrane proteins responsible for the transmission of signals along electrically conducting ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Microbial Platform for Accessing Plant Alkaloids

    SBC: BLACKROCK MICROSYSTEMS, INC            Topic: NINDS

    DESCRIPTION (provided by applicant): In order to successfully use microelectrode arrays for stimulation in chronic implantation, the neural electrode must have longevity and efficacy. Efficacy of stimulation primarily means injecting enough charge to the targeted tissue to elicit action potentials. However, in doing so, the electrode itself must not (1) degrade, (2) generate harmful substances and ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. MEDICAL IMAGING MOTION MONITOR (MIMM)

    SBC: CLEVELAND MEDICAL DEVICES, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Patient motion is a major issue in nuclear medicine imaging studies due to the substantial time to acquire enough counts to produce clinical-quality images. Motion correction algorithms exist but have limited accuracy and effectiveness, and in many instances the only practical alternative is to re-scan the patient. Most work on patient motion sensing has focuse ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Continuous Real Time CSF Shunt Flow Monitor ShuntCheck

    SBC: Annovis Bio, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): A large body of evidence indicates that the cognitive impairment and delayed neurodegeneration in traumatic brain injury (TBI) is caused by increased accumulation of tau, phosphorylated tau (p-tau) and other neurotoxic proteins including APP and alpha-synuclein (aSYN) which also cause neurodegeneration in Alzheimer's Disease (AD) and Parkinson's ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Angiocidin, a Novel Differentiation Agent for the Treatment of Leukemia

    SBC: ALTEC, INC            Topic: NINDS

    DESCRIPTION (provided by applicant): The overall objective of this SBIR project is to develop a pre-commercial prototype system capable of continuously monitoring involuntary movement disorders from a wide spectrum of neurological conditions. The impact ofthis innovation will enhance the availability of advanced brain and behavior research tools [PA- 11-134] by providing a continuous means of trac ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. Small Molecule Inhibitors of ZAP-70 for the Treatment of Autoimmune Disorders

    SBC: INTAN TECHNOLOGIES, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Patch clamp electrophysiology has been a central tool of neuroscience and pharmaceutical research since its advent in the late 1970s. Whole-cell patch clamping utilizes glass micropipettes and sensitive analog electronics to monitor the ion-channel currents and intracellular voltages of individual neurons or other cells. For decades, this has been performed by ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. System for automated noninvasive monitoring of mice

    SBC: SIGNAL SOLUTIONS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): The basic functions of sleep are still unknown. Abnormal sleep patterns can manifest as a variety of disorders-sleep apnea, parasomnias, REM (rapid eye movement sleep) behavioral disorder (RBD), narcolepsy-many of whichare influenced by heredity. There is an increasing focus on characterizing mouse behaviors for genetic and drug studies. However, discovering th ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  10. MyNutritionPlanner: Development and Evaluation of an Innovative Software Approach

    SBC: BIOSTRATAGIES LC            Topic: NINDS

    DESCRIPTION (provided by applicant): The goal of this proposal is to develop an effective enzyme replacement therapy (ERT) for Sanfilippo A patients by exploiting safety, supply, and cost advantages of plant-based enzyme bioproduction while integrating novel ERT delivery strategies being development at BioStrategies LC. Sanfilippo A (MPS-IIIA) is a rare genetic lysosomal storage disorder affecting ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
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