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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201481 - 201490 of 205043 results
  1. Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease

    SBC: HEPROTECH, INC.            Topic: NIAAA

    ? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Gamma-ketoaldehyde scavengers for alcoholic liver disease

    SBC: MTI Biotech Incorporated            Topic: NIAAA

    DESCRIPTION (provided by applicant): Chronic alcohol overconsumption is the third largest risk factor for disease burden worldwide and is a frequent comorbidity of liver disease and cancer. While abstinence is a cornerstone of treatment, there is considerable interest in identifying other therapeutic interventions for alcoholic liver disease (ALD). Such advances are complicated by an incomplete un ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Clinically suitable approach for gene-mediated therapy of cirrhosis.

    SBC: ADVANTAGENE, INC            Topic: NIAAA

    Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Vasoactive Intestinal Peptide for the treatment of Female Sexual Arousal Disorder

    SBC: PharmaIN Corporation            Topic: NIA

    DESCRIPTION (provided by applicant): Female sexual arousal disorder (FSAD), one of the conditions commonly described as Female sexual dysfunction (FSD) is common among older women and can be a significant reason for decreased quality of life in the aging population. FSAD is defined as the persistent or recurring inability to attain or maintain sufficient sexual excitement, causing personal distres ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Mobile Intervention to Enhance Physical Activity in the Chronically Ill

    SBC: Oregon Center For Applied Science, Inc            Topic: NIA

    PROJECT SUMMARY This project aims to fill the urgent need for a safe and engaging intervention that promotes physical activity in a population of patients with chronic diseases (e.g., diabetes, asthma, osteoarthritis, and chronic heart failure). Compelling evidence suggests that physical activity is an effective therapeutic intervention for numerous chronic diseases. However, in spite of the wide ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Algorithm for Free Testosterone Determination

    SBC: FUNCTION PROMOTING THERAPIES LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A synthetic biology platform to identify novel anti-aging natural products

    SBC: Radiant Genomics, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The ultimate goal of research into the biology of aging is to identify pharmaceutical interventions to increase both lifespan and healthspan of humans. The natural product rapamycin has been shown to significantly extend the lifespans of all model organisms tested including fungi, flies, worms, and mice. However, chronic treatment with rapamycin also causes unw ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Clear Cues: Supportive Wayfinding for Care Communities

    SBC: Linda-&-Cameron, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The purpose of this project is to develop and test Clear Cues (CC), a signage system for care communities that supports way finding in people with dementia. Way finding is a process through which people use informationin the environment to help them get to their desired destination. It's both the user experience of choosing a path and the design elements t ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Wearable Vibration Device to Prevent Bone Loss in Postmenopausal Women

    SBC: Theranova LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Osteoporosis affects 10 million Americans over the age of 50 and leads to 1.5 million bone fractures per year, primarily in women. For senior citizens who suffer fractures of the hip, 20% will die within one year. Unfortunately, pharmacological treatments for osteoporosis have been met with resistance due to significant adverse side effects. This project aims ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. A turn-key optogenetics and electrophysiology measurement system

    SBC: Pinnacle Technology, Inc.            Topic: NIA

    ABSTRACT Age-related sleep problems such as advanced sleep phase disorder (ASPD) are estimated to affect at least 1% of middle-aged adults and increase in prevalence with age. While the detrimental effects of sleep disruption with aging are well characterized, detailed insights into the molecular and physiological mechanisms underlying these sleep changes are greatly lacking. Optogenetics harnesse ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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